SUPPRESSION OF THYROID RADIOIODINE UPTAKE BY VARIOUS DOSES OF STABLE IODIDE
SUPPRESSION OF THYROID RADIOIODINE UPTAKE BY VARIOUS DOSES OF STABLE IODIDE
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DOI：
10.1056/nejm198011063031903
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发表时间：
1980-01-01
影响因子：
158.5
通讯作者：
BRAVERMAN, LE
中科院分区：
文献类型：
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作者：
STERNTHAL, E;LIPWORTH, L;BRAVERMAN, LE
在甲状腺功能正常的志愿者中研究了不同剂量NaI对甲状腺放射性碘摄取的影响，方法是单次给予10、30、50和100 mg剂量，然后每日给予10、15、30、50或100 mg剂量，持续12天。10 mg以上的所有单次剂量均抑制24 h甲状腺摄取123 I至0.7- 1.5%。持续每日给予15 mg或更多碘化物导致数值始终低于2%。一个小的，但有统计学意义的下降，血清甲状腺素和三碘甲状腺原氨酸和血清促甲状腺激素浓度上升后，观察到8和12天的碘化物治疗。单次给予30 mg稳定碘化物可显著抑制甲状腺对放射性碘的摄取，并且每日剂量至少为15 mg时可明显维持抑制作用。提供了在暴露于放射性碘的情况下进行稳定碘预防的指南。
The effect of various doses of NaI on thyroid radioiodine uptake was studied in euthyroid volunteers by giving single doses of 10, 30, 50 and 100 mg and then daily doses of 10, 15, 30, 50 or 100 mg for 12 days thereafter. All single doses above 10 mg suppressed 24 h thyroid uptake of 123I to 0.7-1.5%. Continued daily administration of 15 mg of iodide or more resulted in values consistently below 2%. A small but statistically significant fall in serum thyroxine and triiodothyronine and a rise in serum thyrotropin concentrations were observed after 8 and 12 days of iodide treatment. The thyroid uptake of radioactive iodine can be markedly suppressed by single-dose administration of 30 mg of stable iodide, and suppression apparently can be maintained with daily doses of at least 15 mg. Guidelines are provided for stable iodide prophylaxis in the event of exposure to radioactive iodine.