Increased levels of high sensitive C-reactive protein in patients with chronic rheumatic valve disease:: evidence of ongoing inflammation
Increased levels of high sensitive C-reactive protein in patients with chronic rheumatic valve disease:: evidence of ongoing inflammation
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DOI：
10.1016/s1388-9842(02)00102-2
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发表时间：
2002-10-01
影响因子：
18.2
通讯作者：
Aydogdu, S
中科院分区：
文献类型：
--
作者：
Gölbasi, Z;Uçar, Ö;Aydogdu, S
风湿热和风湿性心脏病的确切发病机制(S)一直没有明确的定义。C反应蛋白(CRP)在急性风湿热患者中升高，但在慢性风湿性瓣膜病患者中是否升高尚不清楚。本研究的目的是确定高敏C反应蛋白(hs-CRP)检测的炎症在慢性风湿性瓣膜病进展中的作用。慢性风湿性瓣膜病患者113例(女性81例，男性32例；年龄13~70岁，平均40±14岁)；瓣膜置换术患者51例(女性31例，男性20例；年龄21~71岁，平均48±13岁)；健康体检者102例(女性68例，男性34例，年龄25~73岁，平均41±12岁)。排除急性风湿热、急性感染、炎症性疾病、恶性肿瘤、急性心肌梗死和创伤患者。在BN II分析仪(Behring)上用乳胶增强免疫比浊法测定Hs-CRP。所有患者均行经胸超声心动图检查，以评估瓣膜病变。慢性风湿性心脏病患者hs-CRP值显著高于瓣膜置换组(0.62±0.64比0.35±0.41比0.24+/-0.18 mg/L，P
The precise pathogenetic mechanism(s) of rheumatic fever and rheumatic heart disease have never been defined. C-reactive protein (CRP) is increased in patients with acute rheumatic fever, but it is not known whether plasma levels increase in patients with chronic rheumatic valve disease. The aim of this study was to determine the role of inflammation detected by high sensitivity CRP (hs-CRP) levels in the progression of chronic rheumatic valve disease. A total of 113 patients with chronic rheumatic valve disease (81 women, 32 men; mean age 40 +/- 14 years, range 13-70), 51 patients with prosthetic valve(s) (31 women, 20 men; mean age 48 +/- 13 years, range 21-71) and 102 healthy subjects (68 women, 34 men, mean age 41 +/- 12 years, range 25-73), as a control group, were assessed. Patients with acute rheumatic fever, acute infection, inflammatory disease, malignancy, acute myocardial infarction and trauma were excluded. hs-CRP was determined using latex-enhanced immunonephelometric assays on a BN II analyzer (Behring). Transthoracic echocardiography was performed in all patients in order to evaluate valvular disease. Levels of hs-CRP were significantly higher in patients with chronic rheumatic heart disease than in patients with prosthetic valve(s) and healthy subjects (0.62+/-0.64 vs. 0.35 +/- 0.41 vs. 0.24 +/- 0.18 mg/l, P