Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma
Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma
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DOI：
10.1016/j.ejso.2012.02.001
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发表时间：
2012-08-01
期刊：
影响因子：
3.8
通讯作者：
Zhao, J.
中科院分区：
文献类型：
--
作者：
Hao, R. T.;Chen, J.;Zhao, J.
目的：比较亚甲蓝（MB）和纳米碳（CNs）作为前哨淋巴结活检（SLNB）示踪剂的疗效，评估SLNB在预测甲状腺微小癌患者颈部LN状态中的价值。 方法：本回顾性分析包括200例接受术中SLNB的甲状腺微小癌患者。其中，100名患者接受了MB染料注射。另外 100 名患者接受 CN 混悬液注射。所有切除标本均进行常规病理检查。结果：实验组和对照组检测到的SLN分别为126个和102个，其中经组织病理学证实的转移性LN分别为77个和48个。实验组宫颈VI级LN染色率显着高于对照组（P < 0.001）。 CN方法的敏感性、特异性、准确率和假阴性率分别为93.3%、100%、97%和5.2%，而MB方法的相应数字分别为80.6%、100%、93%和9.9%。实验组SLNs癌转移阳性率为61.1%，显着高于对照组（47.1%；P=0.034）。结论：与MB法相比，CNs可以保持SLN成像的持久性，准确预测甲状腺微小癌患者的LN状态；此外，CN 方法被认为是可行且可重复的。 CN 方法更好地帮助筛选和选择最有可能从宫颈淋巴结清扫术中受益的患者。 (C) 2012 Elsevier Ltd. 保留所有权利。
Aims: To compare the efficacies of methylene blue (MB) and carbon nanoparticles (CNs) as tracers for sentinel lymph node biopsy (SLNB), and assess the value of SLNB in predicting the cervical LN status of patients with thyroid microcarcinoma.Methods: This retrospective analysis comprised 200 thyroid microcarcinoma patients who underwent intraoperative SLNB. Among them, 100 patients were injected with MB dye. The other 100 patients received a CN suspension injection. Routine pathological examination was performed in all resected specimens.Results: SLNs detected in the experimental and control groups were 126 and 102, respectively, of which the metastatic LNs confirmed by histopathology were 77 and 48, respectively. The staining rate of cervical level VI LNs in the experimental group was significantly higher than that in the control group (P < 0.001). For the CN method, the sensitivity, specificity, accuracy rate, and false negative rate were 93.3%, 100%, 97%, and 5.2%, respectively, whereas the corresponding figures for the MB method were 80.6%, 100%, 93%, and 9.9%, respectively. The positive rate of cancer metastases for SLNs in the experimental group was 61.1%, which is significantly higher than that in the control group (47.1%; P = 0.034).Conclusions: In contrast to the MB method, CNs can maintain the durability of SLN imaging and accurately forecast the LN status of patients with thyroid microcarcinoma; in addition, the CN method was found to be feasible and repeatable. The CN method better aids the screening and selection of patients who are most likely to benefit from cervical LN dissection. (C) 2012 Elsevier Ltd. All rights reserved.