Wave optics simulation of grating‐based X‐ray phase‐contrast imaging using 4D Mouse Whole Body (MOBY) phantom
Wave optics simulation of grating‐based X‐ray phase‐contrast imaging using 4D Mouse Whole Body (MOBY) phantom
复制标题
使用 4D 小鼠全身 (MOBY) 体模进行基于光栅的 X 射线相位对比成像的波动光学模拟
DOI：
10.1002/mp.14479
复制
发表时间：
2020
期刊：
影响因子：
3.8
通讯作者：
Graves, William S.
中科院分区：
文献类型：
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作者：
Sung, Yongjin;Nelson, Brandon;Shanblatt, Elisabeth R.;Gupta, Rajiv;McCollough, Cynthia H.;Graves, William S.
目的演示使用波动光学和非均匀有理 B 样条 (NURBS) 定义的四维小鼠全身 (MOBY) 体模对基于光栅的 X 射线相衬成像 (GB-XPCI) 的真实模拟。方法我们使用全波方法，该方法使用波动光学将 X 射线波从源传播到探测器。这种正向成像模型可以直接应用于 NURBS 定义的数值模型，例如 MOBY。我们使用成人组织的数据分配每个模型部件的材料属性（衰减系数和电子密度）。根据计算出的每个像素的光子通量，将泊松噪声添加到模拟图像中。结果我们模拟了 MOBY 体模八个不同光栅位置的强度图像。根据模拟图像，我们计算吸收、微分相位和归一化可见度对比度图像。我们还预测了不同曝光时间对图像质量的影响。结论GB-XPCI 可以使用全波方法和 NURBS 定义的真实数值模型进行模拟。
PurposeDemonstrate realistic simulation of grating‐based x‐ray phase‐contrast imaging (GB‐XPCI) using wave optics and the four‐dimensional Mouse Whole Body (MOBY) phantom defined with non‐uniform rational B‐splines (NURBS).MethodsWe use a full‐wave approach, which uses wave optics for x‐ray wave propagation from the source to the detector. This forward imaging model can be directly applied to NURBS‐defined numerical phantoms such as MOBY. We assign the material properties (attenuation coefficient and electron density) of each model part using the data for adult human tissues. The Poisson noise is added to the simulated images based on the calculated photon flux at each pixel.ResultsWe simulate the intensity images of the MOBY phantom for eight different grating positions. From the simulated images, we calculate the absorption, differential phase, and normalized visibility contrast images. We also predict how the image quality is affected by different exposure times.ConclusionsGB‐XPCI can be simulated with the full‐wave approach and a realistic numerical phantom defined with NURBS.