Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression
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DOI：
10.1016/s1471-4892(01)00117-5
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发表时间：
2002-02-01
影响因子：
4
通讯作者：
Holsboer, F
中科院分区：
文献类型：
--
作者：
Reul, JMHM;Holsboer, F
促肾上腺皮质激素释放因子（CRF）及其相关家族成员与焦虑、抑郁等应激相关疾病有关。最近，在大脑中发现了这一神经肽家族的两个新成员：尿皮质素11（也称为应激相关肽）和尿皮质素III（也称为应激相关肽）。这些尿皮质素是CRF2受体的选择性激动剂，显示出独特的神经解剖学定位，并参与应激应对反应，如焦虑缓解。因此，CRF、尿皮质素及其受体在大脑中形成了一个复杂的网络，参与应激反应的急性期和恢复期。
Corticotropin-releasing factor (CRF) and its related family members are implicated in stress-related disorders such as anxiety and depression. Recently, two new members of this neuropeptide family have been discovered in the brain: urocortin 11 (also known as stresscopin-related peptide) and urocortin III (also known as stresscopin). These urocortins are selective agonists for the CRF2 receptor, show a distinct neuroanatomical localization and are involved in stress-coping responses such as anxiolysis. Thus, CRF the urocortins and their receptors form an intricate network in the brain involved in the acute phase as well as the recovery phase of the stress response.