Clinical Significance of Yes-Associated Protein Overexpression in Cervical Carcinoma The Differential Effects Based on Histotypes
Clinical Significance of Yes-Associated Protein Overexpression in Cervical Carcinoma The Differential Effects Based on Histotypes
复制标题
DOI：
10.1097/igc.0b013e31828c8619
复制
发表时间：
2013-05-01
影响因子：
4.8
通讯作者：
Lou, Ge
中科院分区：
文献类型：
--
作者：
Liu, Tianbo;Liu, Yunduo;Lou, Ge
目的：本研究的目的是探讨 Yes 相关蛋白（YAP）表达在宫颈癌中的预后价值。方法：采用免疫组化方法比较 120 例鳞状细胞癌（SCC）样本和 42 例腺癌样本与 22 例正常宫颈标本中 YAP 的表达情况。分别分析细胞质和细胞核中YAP的表达情况。结果：Yes相关蛋白在肿瘤中的表达量显着高于正常组织中的水平。在 SCC 中，细胞质 YAP 表达与组织学分级、淋巴结转移和复发相关。 SCC 中不存在 YAP 的核表达。在腺癌中，细胞质 YAP 过度表达与组织学分级相关，细胞核过度表达与较短的总生存期和无病生存期相关。结论：我们的结果表明 YAP 在宫颈癌中的致癌潜力及其在鳞状细胞癌和腺癌中的独特功能。
Objectives: The objective of this study was to explore the prognostic values of Yes-associated protein (YAP) expression in cervical carcinoma.Methods: We compared the YAP expression of 120 samples from squamous cell carcinomas (SCCs) and 42 samples from adenocarcinomas with 22 normal cervical specimens by immunohistochemistry. The expressions of cytoplasmic and nuclear YAP were analyzed separately.Result: Yes-associated protein expression in tumors is significantly higher than the level in normal tissues. In SCCs, cytoplasmic YAP expression is associated with histologic grading, lymph node metastasis, and recurrence. Nuclear expression of YAP is absent in SCC. In adenocarcinomas, cytoplasmic YAP overexpression is associated with histologic grading, and nuclear overexpression is associated with shorter overall survival and disease-free survival.Conclusions: Our results indicate the oncogenic potential of YAP in cervical cancer and its distinct functions in SCC and adenocarcinoma.