Response correlation maps of neurons in the mammalian olfactory bulb
Response correlation maps of neurons in the mammalian olfactory bulb
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DOI：
10.1016/s0896-6273(01)00537-2
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发表时间：
2001-12-26
期刊：
影响因子：
16.2
通讯作者：
Katz, LC
中科院分区：
文献类型：
--
作者：
Luo, M;Katz, LC
为了确定肾小球激活模式与主嗅球神经元嗅觉反应之间的关系，将细胞内记录与固有信号的光学成像相结合。通过将闻到气味时膜电位和放电率的波动与肾小球的激活模式相关联，构建了反应相关图（RCMs）。RCMs显示二尖瓣/簇状细胞通过激活其主要肾小球周围的局灶区域而兴奋，并且通常被更远处区域的激活所抑制。然而，在使用气味剂期间和之后，RCMs的结构以及兴奋性和抑制性肾小球输入的相对贡献发生了演变，甚至改变了信号。这些数据表明二尖瓣/簇状细胞接受野的动态中心-环绕组织。
To define the relationship between glomerular activation patterns and neuronal olfactory responses in the main olfactory bulb, intracellular recordings were combined with optical imaging of intrinsic signals. Response correlation maps (RCMs) were constructed by correlating the fluctuations in membrane potential and firing rate during odorant presentations with patterns of glomerular activation. The RCMs indicated that mitral/tufted cells were excited by activation of a focal region surrounding their principal glomerulus and generally inhibited by activation of more distant regions. However, the structure of the RCMs and the relative contribution of excitatory and inhibitory glomerular input evolved and even changed sign during and after odorant application. These data suggest a dynamic center-surround organization of mitral/tufted cell receptive fields.