Local blood flow changes in the renal cortex during tourniquet and burn shock in rats.
Local blood flow changes in the renal cortex during tourniquet and burn shock in rats.
复制标题
大鼠止血带和烧伤休克期间肾皮质局部血流变化。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
A. Kirkebø
中科院分区：
文献类型：
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作者：
A. Haugan;A. Kirkebø
在犬创伤性休克期间，观察到肾皮质间歇性斑片状缺血。为了寻找进一步研究麻醉大鼠这种现象的模型，我们通过双侧后肢闭塞3 1/2小时诱导止血带休克，并通过在90 ℃水中烫伤后肢50%体表30秒诱导烧伤休克。局部皮质血流量（RCF）重复测量的H2冲洗技术。释放止血带后，平均动脉压（AP）和RCF分别下降44%和68%，而红细胞压积（Hct）上升至66 vol%。仅观察到两次局部缺血。烫伤后，Hct首先下降到49体积%，可能是由于溶血，但在接下来的2小时内上升到54体积%。在初始下降至99 mmHg之后，AP在整个实验中相对良好地维持。RCF在15 min内降至对照的53%，在接下来的2 h内进一步降至40%。皮层血管阻力增加89%。在8只大鼠中的6只中观察到局部血流异质性增加和斑片状间歇性缺血发作。在烧伤后第二个小时，21%的洗脱曲线显示洗脱率的突然变化，表明局部皮质缺血。烧伤休克模型似乎非常适合于研究引起间歇性局部缺血的机制。
Intermittent patchy ischemia in the renal cortex has been observed in dogs during traumatic shock. In search of a model for further studies of this phenomenon in anesthetized rats, we induced tourniquet shock by bilateral hindlimb occlusion for 3 1/2 h, and burn shock by scalding the hind 50% of body surface for 30 sec in 90 degrees C water. Local cortical blood flow (RCF) was repeatedly measured by the H2-washout technique. After releasing the tourniquets, mean arterial pressure (AP) and RCF decreased by 44 and 68% whereas hematocrit (Hct) rose to 66 vol%. Only two episodes of local ischemia were observed. After scalding, Hct first fell to 49 vol%, probably due to hemolysis, but rose toward 54 vol% in the next 2 h. Following an initial drop to 99 mmHg, AP was relatively well maintained throughout the experiment. The RCF fell to 53% of control within 15 min with a further decrease to 40% during the next 2 h. The cortical vascular resistance was increased by 89%. Increased local flow heterogeneity and episodes of patchy intermittent ischemia were observed in six out of eight rats. During the second hour postburn, 21% of the washout curves showed abrupt shifts of washout rates, indicating local cortical ischemia. The burn shock model seems well suited for studies of the mechanisms causing intermittent local ischemia.