Orotic acid, a promoter of liver carcinogenesis induces DNA damage in rat liver.
Orotic acid, a promoter of liver carcinogenesis induces DNA damage in rat liver.
复制标题
乳清酸是肝癌发生的促进剂，可诱导大鼠肝脏 DNA 损伤。
DOI：
10.1093/carcin/6.5.765
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发表时间：
1985
期刊：
影响因子：
4.7
通讯作者：
Parodi,S
中科院分区：
文献类型：
--
作者：
Rao,PM;Rajalakshmi,S;Alam,A;Sarma,DS;Pala,M;Parodi,S
乳清酸是嘧啶核苷酸生物合成的前体，也是肝癌发生的促进剂，当以1%的水平在饲料中喂养5周时，会导致肝脏DNA损伤。可使用碱性蔗糖梯度以及碱性洗脱技术将损伤监测为碱不稳定性损伤。此外，诱导的DNA损伤在停止乳清酸饮食后持续长达三周。几种皮肤肿瘤促进剂也诱导DNA损伤的流行提出了DNA损伤是否是肿瘤促进的一个组成部分的问题。
Orotic acid, a precursor of pyrimidine nucleotide biosynthesis and a promoter for liver carcinogenesis, when fed at 1% level in a diet for 5 weeks resulted in liver DNA damage. The damage can be monitored as alkali-labile lesions using alkaline sucrose gradients as well as alkaline elution technique. Furthermore, the induced DNA damage persists for up to three weeks after withdrawal of the orotic acid diet. The fad that several skin-tumour promoters also induce DNA damage raises the question whether DNA damage is a component in tumour promotion.