Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support.
Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support.
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DOI：
10.1111/j.1525-1594.2007.00401.x
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发表时间：
2007-05
影响因子：
2.4
通讯作者：
K. Ohuchi;H. Hoshi;Y. Iwasaki;K. Ishihara;M. Yoshikawa;S. Ugaki;K. Ishino;S. Osaki;Y. Kotani;S. Sano;S. Takatani
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文献类型：
--
作者：
K. Ohuchi;H. Hoshi;Y. Iwasaki;K. Ishihara;M. Yoshikawa;S. Ugaki;K. Ishino;S. Osaki;Y. Kotani;S. Sano;S. Takatani
在本研究中，TinyPump（预充体积5 mL）系统的性能包括儿科插管（Stöckert儿科动脉插管2.6、3.0和4.0 mm，Stöckert Instruments GmbH，慕尼黑，德国; Polystan 20-Fr静脉导管，MAQUET GmbH，Rastatt，德国）和氧合器（Terumo Capiox RX 05 Baby-RX，Terumo Cardiovascular Systems Co.，Tokyo，Japan）进行体外研究，然后在20-kg仔猪中进行初步离体研究。体外结果表明，TinyPump系统满足儿科患者心脏直视手术和体外膜肺氧合（ECMO）期间作为体外循环支持的泵速、泵流量和压降要求。在使用20公斤小猪的2小时离体研究中，TinyPump的血液接触表面涂有生物相容性磷脂聚合物，无血浆血红蛋白水平保持低于5.0 mg/dL，并且在泵内没有观察到血栓形成。TinyPump系统（包括氧合器和连接回路）的总预充量为68 mL，是有史以来报告的最小预充量。TinyPump是心脏直视手术和ECMO期间儿科循环支持的安全选择，无需输血。
In this study, the performances of the TinyPump (priming volume 5 mL) system including the pediatric cannulae (Stöckert Pediatric Arterial Cannulae 2.6, 3.0, and 4.0 mm, Stöckert Instruments GmbH, Munich, Germany; Polystan 20-Fr Venous Catheter, MAQUET GmbH, Rastatt, Germany) and an oxygenator (Terumo Capiox RX05 Baby-RX, Terumo Cardiovascular Systems Co., Tokyo, Japan) were studied in vitro followed with preliminary ex vivo studies in 20-kg piglets. In vitro results revealed that the TinyPump system met the requirements for pump speed, pump flow, and pressure drop as extracorporeal circulatory support during open heart surgery and extracorporeal membrane oxygenation (ECMO) in pediatric patients. In 2-h ex vivo studies using 20-kg piglets where the blood contacting surface of the TinyPump was coated with a biocompatible phospholipid polymer, the plasma-free hemoglobin levels remained less than 5.0 mg/dL and no thrombus formation was observed inside the pump. The TinyPump system including the oxygenator and connecting circuits resulted in an overall priming volume of 68 mL, the smallest ever reported. The TinyPump can be a safe option for pediatric circulatory support during open heart surgery and ECMO without requiring blood transfusion.