Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
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DOI：
10.1210/jcem.86.3.7316
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发表时间：
2001-03
期刊：
影响因子：
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通讯作者：
Robert B. Fogel;A. Malhotra;G. Pillar;Stephen D. Pittman;A. Dunaif;D. White
中科院分区：
文献类型：
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作者：
Robert B. Fogel;A. Malhotra;G. Pillar;Stephen D. Pittman;A. Dunaif;D. White
阻塞性睡眠呼吸暂停（OSA）在男性中比女性更常见。初步数据表明，雄激素可能在男性占主导地位的呼吸暂停中发挥作用。多囊卵巢综合征（PCOS）的特征是月经紊乱，雄激素过多，经常肥胖。这些特征表明，患有PCOS的女性可能会增加OSA的风险。为了确定肥胖多囊卵巢综合征妇女与年龄和体重相匹配的正常生育妇女相比，睡眠呼吸暂停的患病率是否增加，我们对18名肥胖多囊卵巢综合征妇女和年龄和体重相匹配的对照妇女进行了夜间多导睡眠描记术，以确定呼吸暂停低通气指数（AHI）。其他测量包括腰围、臀围和颈围、血清总睾酮、未结合睾酮和DHEAS。PCOS患者的AHI高于对照组（22.5 +/- 6.0 vs. 6.7 +/- 1.0，P = 0.008）。多囊卵巢综合征的女性也更容易患症状性OSA综合征（44.4%比5.5%，P = 0.008）。PCOS组AHI与腰臀比（r = 0.51，P < 0.03）、血清睾酮（r = 0.52，P < 0.03）和游离睾酮（r = 0.50，P < 0.05）相关。我们的结论是，与生育正常的女性相比，肥胖的PCOS女性患OSA的风险增加。PCOS患者应仔细询问睡眠呼吸暂停的症状。
Obstructive Sleep Apnea (OSA) is considerably more common in men than women. Preliminary data suggest that androgens may play a role in the male predominance of apnea. Polycystic Ovary Syndrome (PCOS) is characterized by menstrual disturbances, androgen excess, and frequently obesity. These features suggest that women with PCOS may be at increased risk for OSA. To determine whether obese women with PCOS have an increased prevalence of sleep apnea compared with age and weight-matched reproductively normal women, we performed overnight polysomnography for determination of the apnea-hypopnea index (AHI) in 18 obese women with PCOS and age and weight-matched control women. Additional measurements included waist, hip, and neck circumferences, serum total testosterone, unbound testosterone, and DHEAS. Women with PCOS had a higher AHI than controls (22.5 +/- 6.0, vs. 6.7 +/- 1.0, P = 0.008). Women with PCOS were also more likely to suffer from symptomatic OSA syndrome (44.4% vs. 5.5%, P = 0.008). AHI correlated with waist-hip ratio (r = 0.51, P < 0.03), serum testosterone (r = 0.52, P < 0.03) and unbound testosterone (r = 0.50, P < 0.05) in women with PCOS. We conclude that obese women with PCOS are at increased risk of OSA when compared with matched reproductively normal women. Women with PCOS should be carefully questioned regarding symptoms of sleep apnea.