Background Parenchymal Enhancement at Breast MR Imaging and Breast Cancer Risk
Background Parenchymal Enhancement at Breast MR Imaging and Breast Cancer Risk
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DOI：
10.1148/radiol.11102156
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发表时间：
2011-07-01
期刊：
影响因子：
19.7
通讯作者：
Morris, Elizabeth A.
中科院分区：
文献类型：
--
作者：
King, Valencia;Brooks, Jennifer D.;Morris, Elizabeth A.
目的：探讨乳腺癌与磁共振（MR）成像纤维腺组织（FGT）数量和背景实质增强（BPE）水平的关系。材料和方法：机构审查委员会批准了这项符合hipaa的回顾性研究的豁免授权。在2002年12月至2008年2月期间接受乳腺磁共振成像筛查的1275名女性中，发现了39例乳腺癌病例。进行了两项比较：在一项比较中，根据年龄和磁共振成像日期，将两名正常对照——乳腺磁共振成像阴性（良性）的女性——与每名乳腺癌病例相匹配。在第二次比较中，一个假阳性对照——一个在磁共振成像中有可疑但非恶性发现的女性——与每个乳腺癌病例相似。两位读者使用分类量表独立评定MR成像描绘的BPE的水平和MR成像描绘的FGT的数量：BPE被分类为轻微、轻度、中度或显著，FGT被分类为脂肪、分散、非均匀致密或致密。结果：与正常对照的比值比（OR）相比，乳腺癌的比值比随着BPE的增加而显著增加：读者1和读者2中度或显著性BPE与轻度或轻度BPE的比值比分别为10.1（95%可信区间[CI]: 2.9, 35.3; P < 0.001）和3.3 （95% CI: 1.3, 8.3; P = 0.006）。当假阳性对照与乳腺癌病例比较时，也发现了类似的几率：读者1和读者2的中度或显著性BPE与轻度或轻度BPE的or分别为5.1 （95% CI: 1.4, 19.1; P = 0.005）和3.7 （95% CI: 1.2, 11.2; P = 0.013）。乳腺癌的几率也随着FGT的增加而增加，但调整FGT后BPE结果仍然显著。结论：BPE增高是乳腺癌发病的重要预测指标。(c) rsna, 2011
Purpose: To examine the relationships between breast cancer and both amount of fibroglandular tissue (FGT) and level of background parenchymal enhancement (BPE) at magnetic resonance (MR) imaging.Materials and Methods: A waiver of authorization was granted by the institutional review board for this retrospective HIPAA-compliant study. Among 1275 women who underwent breast MR imaging screening between December 2002 and February 2008, 39 breast carcinoma cases were identified. Two comparisons were performed: In one comparison, two normal controls-those of the women with negative (benign) findings at breast MR imaging-were matched to each breast cancer case on the basis of age and date of MR imaging. In the second comparison, one false-positive control-that of a woman with suspicious but nonmalignant findings at MR imaging-was similarly matched to each breast cancer case. Two readers independently rated the level of MR imaging-depicted BPE and the amount of MR imaging-depicted FGT by using a categorical scale: BPE was categorized as minimal, mild, moderate, or marked, and FGT was categorized as fatty, scattered, heterogeneously dense, or dense.Results: Compared with the odds ratio (OR) for a normal control, the OR for breast cancer increased significantly with increasing BPE: The ORs for moderate or marked BPE versus minimal or mild BPE were 10.1 (95% confidence interval [CI]: 2.9, 35.3; P < .001) and 3.3 (95% CI: 1.3, 8.3; P = .006) for readers 1 and 2, respectively. Similar odds were seen when the false-positive controls were compared with the breast cancer cases: The ORs for moderate or marked BPE versus minimal or mild BPE were 5.1 (95% CI: 1.4, 19.1; P = .005) and 3.7 (95% CI: 1.2, 11.2; P = .013) for readers 1 and 2, respectively. The breast cancer odds also increased with increasing FGT, but the BPE findings remained significant after adjustment for FGT.Conclusion: Increased BPE is strongly predictive of breast cancer odds. (C) RSNA, 2011