Decoding cognitive control in human parietal cortex
Decoding cognitive control in human parietal cortex
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DOI：
10.1073/pnas.0903593106
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发表时间：
2009-10-20
影响因子：
11.1
通讯作者：
Yantis, Steven
中科院分区：
文献类型：
--
作者：
Esterman, Michael;Chiu, Yu-Chin;Yantis, Steven
感知运动任务的有效执行需要随着情况的发展而快速自愿地重新配置认知任务集。这种认知控制行为被认为依赖于前额叶和后顶叶皮层的皮质区域网络，包括在知觉输入或记忆表征之间自愿转移注意力，或者在分类或刺激反应映射规则之间切换。一个尚未解答的关键问题是，这些不同领域中的任务集转移是由通用的、独立于领域的机制控制的，还是由单独的、特定于领域的机制控制的。最近的研究表明，内侧上顶小叶（mSPL）的一个共同区域是在知觉、助记和规则表征之间转换期间认知控制的独立于域的来源。在这里，我们使用功能磁共振成像和事件相关的多体素模式分类来表明 mSPL 内大脑活动的空间模式可靠地表达了认知控制的几个领域中的哪一个在每时每刻都在发挥作用。至关重要的是，这些时空大脑模式在相隔几个月进行测试的受试者中以及在各种任务中保持稳定，包括转移视觉空间注意力、切换分类规则和转移工作记忆中的注意力。
Efficient execution of perceptual-motor tasks requires rapid voluntary reconfiguration of cognitive task sets as circumstances unfold. Such acts of cognitive control, which are thought to rely on a network of cortical regions in prefrontal and posterior parietal cortex, include voluntary shifts of attention among perceptual inputs or among memory representations, or switches between categorization or stimulus-response mapping rules. A critical unanswered question is whether task set shifts in these different domains are controlled by a common, domain-independent mechanism or by separate, domain-specific mechanisms. Recent studies have implicated a common region of medial superior parietal lobule (mSPL) as a domain-independent source of cognitive control during shifts between perceptual, mnemonic, and rule representations. Here, we use fMRI and event-related multivoxel pattern classification to show that spatial patterns of brain activity within mSPL reliably express which of several domains of cognitive control is at play on a moment-by-moment basis. Critically, these spatio-temporal brain patterns are stable over time within subjects tested several months apart and across a variety of tasks, including shifting visuospatial attention, switching categorization rules, and shifting attention in working memory.