Gestational trophoblastic disease
Gestational trophoblastic disease
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DOI：
10.1016/s0140-6736(10)60280-2
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发表时间：
2010-08-01
期刊：
影响因子：
168.9
通讯作者：
Berkowitz, Ross S.
中科院分区：
文献类型：
--
作者：
Seckl, Michael J.;Sebire, Neil J.;Berkowitz, Ross S.
妊娠滋养细胞疾病包括一系列与妊娠相关的疾病，包括完全性和部分性葡萄胎的癌前疾病，以及侵袭性葡萄胎、绒毛膜癌和罕见的胎盘部位滋养细胞肿瘤的恶性疾病。这些恶性形式被称为妊娠滋养细胞肿瘤或瘤形成。管理和随访方案的改进意味着总体治愈率可以超过 98%，同时保留生育能力，而 60 年前大多数女性可能会死于恶性疾病。这一成功可以通过有效治疗方法的开发、使用人绒毛膜促性腺激素作为生物标志物以及集中护理来解释。我们总结了妊娠滋养细胞疾病的治疗策略，并解决了一些争议和未来的研究方向。
Gestational trophoblastic disease encompasses a range of pregnancy-related disorders, consisting of the premalignant disorders of complete and partial hydatidiform mole, and the malignant disorders of invasive mole, choriocarcinoma, and the rare placental-site trophoblastic tumour. These malignant forms are termed gestational trophoblastic tumours or neoplasia. Improvements in management and follow-up protocols mean that overall cure rates can exceed 98% with fertility retention, whereas most women would have died from malignant disease 60 years ago This success can be explained by the development of effective treatments, the use of human chorionic gonadotropin as a biomarker, and centralisation of care. We summarise strategies for management of gestational trophoblastic disease and address some of the controversies and future research directions.