Risk of thyroid cancer after exposure to 131I in childhood
Risk of thyroid cancer after exposure to 131I in childhood
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DOI：
10.1093/jnci/dji129
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发表时间：
2005-05-18
影响因子：
10.3
通讯作者：
Williams, D
中科院分区：
文献类型：
--
作者：
Cardis, E;Kesminiene, A;Williams, D
背景资料。1986年4月切尔诺贝利核电站事故发生后，据报道，受污染地区儿童甲状腺癌发病率大幅增加。对甲状腺的辐射大部分来自碘同位素，特别是I-131。我们在白俄罗斯和俄罗斯联邦开展了一项以人群为基础的甲状腺癌病例对照研究，以评估儿童时期接触放射性碘后患甲状腺癌的风险，并调查可能改变这种风险的环境和宿主因素。方法：我们研究了1998年收治的276例甲状腺癌患者和1300名匹配的对照组，他们在事故发生时年龄均小于15岁。根据每个受试者在事故发生时的行踪和饮食习惯以及在接下来的几天、几周和几年内，对每个受试者的个人剂量进行了估计；还评估了他们在事故发生时可能处于稳定的碘状态。使用几种不同的模型对数据进行条件Logistic回归分析。所有的统计检验都是双面的。结果：儿童接受的甲状腺辐射剂量与患甲状腺癌的危险性之间存在明显的剂量-反应关系(P
Background. After the Chernobyl nuclear power plant accident in April 1986, a large increase in the incidence of childhood thyroid cancer was reported in contaminated areas. Most of the radiation exposure to the thyroid was from iodine isotopes, especially I-131. We carried out a population-based case-control study of thyroid cancer in Belarus and the Russian Federation to evaluate the risk of thyroid cancer after exposure to radioactive iodine in childhood and to investigate environmental and host factors that may modify this risk. Methods: We studied 276 case patients with thyroid cancer through 1998 and 1300 matched control subjects, all aged younger than 15 years at the time of the accident. Individual doses were estimated for each subject based on their whereabouts and dietary habits at the time of the accident and in following days, weeks, and years; their likely stable iodine status at the time of the accident was also evaluated. Data were analyzed by conditional logistic regression using several different models. All statistical tests were two-sided. Results: A strong dose-response relationship was observed between radiation dose to the thyroid received in childhood and thyroid cancer risk (P