Bioactive 3,8‐Epoxy Iridoids from Valeriana jatamansi
Bioactive 3,8‐Epoxy Iridoids from Valeriana jatamansi
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DOI：
10.1002/cbdv.201800474
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发表时间：
2019-05
影响因子：
2.9
通讯作者：
Li-Qiu Quan;Li-Hua Su;Shi‐Gang Qi;Yong Xue;Tao Yang;Dan Liu;Xu-Dong Zhao;Rong-Tao Li;Hong-mei Li
中科院分区：
文献类型：
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作者：
Li-Qiu Quan;Li-Hua Su;Shi‐Gang Qi;Yong Xue;Tao Yang;Dan Liu;Xu-Dong Zhao;Rong-Tao Li;Hong-mei Li
从缬草的根和根茎中获得了 12 种 3,8-环氧环烯醚萜类化合物，包括四种新化合物 Jatamanins R–U (1–4) 和八种已知化合物 (5–12)。通过光谱数据分析阐明了结构。 1-4 的绝对构型是通过比较实验和文献 ECD 光谱来确定的。此外，还评估了这些化合物对神经胶质瘤干细胞的细胞毒性作用、对 NO 产生的抑制、对甲型流感病毒的活性以及逆转 HepG2/ADR 细胞的多药耐药性。化合物 9 和 12 对 GSC-18#（IC50 分别为 1.351 和 4.439 μg ml-1）和 GSC-3#（IC50 分别为 10.88 和 6.348 μg ml-1）神经胶质瘤干细胞显示出显着的细胞毒性效力，而化合物 12 对 GSC-12# 的效力也稍差（IC50=13.45 μg） ml−1) 神经胶质瘤干细胞生长。此外，化合物9和12对NO产生具有明显的抑制作用（IC50分别为4.6和15.8 μm）。
Twelve 3,8‐epoxy iridoids, including four new compounds, jatamanins R–U (1–4), and eight known compounds (5–12), were obtained from the roots and rhizomes of Valeriana jatamansi. The structures were elucidated from analysis of spectroscopic data. The absolute configurations of 1–4 were determined by comparison of experimental and literature ECD spectra. Moreover, the compounds were evaluated for cytotoxic effects against glioma stem cells, inhibition of NO production, activity against influenza A virus and reversal of multidrug resistance of HepG2/ADR cells. Compounds 9 and 12 showed significant cytotoxic potency against GSC‐18# (IC50=1.351 and 4.439 μg ml−1, respectively) and GSC‐3# (IC50=10.88 and 6.348 μg ml−1, respectively) glioma stem cells, while compound 12 was also slightly less potent against GSC‐12# (IC50=13.45 μg ml−1) glioma stem cell growth. In addition, compounds 9 and 12 displayed obvious inhibition of NO production (IC50=4.6 and 15.8 μm, respectively).