Euphylonoids A and B, Two Highly Modified Jatrophane Diterpenoids with Potent Lipid-Lowering Activity from Euphorbia hylonoma.
Euphylonoids A and B, Two Highly Modified Jatrophane Diterpenoids with Potent Lipid-Lowering Activity from Euphorbia hylonoma.
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DOI：
10.1021/acs.orglett.2c03649
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发表时间：
2022-11
期刊：
影响因子：
5.2
通讯作者：
Shuge Wu;Run-Zhu Fan;Fang-yu Yuan;Wei Li;Dong Huang;Shen Li;G. Tang;Zhishu Huang;Sheng Yin
中科院分区：
文献类型：
--
作者：
Shuge Wu;Run-Zhu Fan;Fang-yu Yuan;Wei Li;Dong Huang;Shen Li;G. Tang;Zhishu Huang;Sheng Yin
从大戟属植物中分离得到两种高度修饰的麻风碱二萜类化合物：大戟类A(1)和B(2)。1代表一个新的9(10→18)-abeo-8,12-环麻atrophane骨架，包含一个笼状的3,8-二恶四环[5.1.2.04,9]十烷骨架，而2是一个14(13→20)-abeo-8,12-环麻atrophane骨架，具有一个不寻常的17-恶四环[12.2.1.01,5.09,13]十七烷骨架。它们的结构通过光谱、化学、计算和单晶x射线衍射等手段进行了解析。2通过激活amp激活的蛋白激酶信号，显著抑制3T3-L1脂肪细胞的早期脂肪形成。
Euphylonoids A (1) and B (2), two highly modified jatrophane diterpenoids, were isolated from Euphorbia hylonoma. 1 represents a new 9(10→18)-abeo-8,12-cyclojatrophane skeleton containing a cage-like 3,8-dioxatricyclo[5.1.2.04,9]decane core, while 2 is a 14(13→20)-abeo-8,12-cyclojatrophane featuring an unusual 17-oxatetracyclo[12.2.1.01,5.09,13]heptadecane framework. Their structural elucidation was completed by spectroscopic, chemical, computational, and single-crystal X-ray diffraction means. 2 significantly inhibited early adipogenesis in 3T3-L1 adipocytes via activating AMP-activated protein kinase signaling.