Stem cell therapy is proarrhythmic.
Stem cell therapy is proarrhythmic.
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DOI：
10.1161/circulationaha.108.779900
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发表时间：
2009-04-07
期刊：
影响因子：
37.8
通讯作者：
Boyden PA
中科院分区：
文献类型：
--
作者：
Macia E;Boyden PA
1814已经被植入缺血的大脑。11研究已经描述了未分化和分化MSC中的离子电流的补充，12，13导致细胞具有30至40 mV范围内的静息电位。其他研究已经描述了关键的心脏蛋白，如肌钙蛋白-I和连接蛋白43（Cx43）。MSC是否完全分化为心脏细胞类型仍然存在争议。十五，十六
1814 have been implanted into the ischemic brain. 11 Studies have described a complement of ionic currents in both the undifferentiated and differentiated MSC, 12, 13 resulting in cells with resting potentials in the 30 to 40 mV range. Other studies have described critical cardiac proteins such as troponin-I and connexin 43 (Cx43). 14 Whether MSCs fully differentiate into cardiac cell types remains controversial. 15, 16