The role of centrosomes in fertilization, cell division and establishment of asymmetry during embryo development.
The role of centrosomes in fertilization, cell division and establishment of asymmetry during embryo development.
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DOI：
10.1016/j.semcdb.2010.01.012
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发表时间：
2010-04
影响因子：
7.3
通讯作者：
H. Schatten;Qing-Yuan Sun
中科院分区：
文献类型：
--
作者：
H. Schatten;Qing-Yuan Sun
中心体在生殖、细胞分裂、胚胎发育和干细胞生物学中发挥着重要的中心作用，在过去的十年中积累了丰富的新信息，涵盖了各种细胞活动中特定中心体蛋白的分子细节和新发现的功能/功能障碍。本文就生殖细胞中心体在受精过程中的作用、合子中心体的形成、首次胚胎细胞分裂过程中中心体的复制和分离、细胞分化和胚胎发育过程中的不对称细胞分裂等方面的研究进展作一综述。它还将讨论干细胞的不对称细胞分裂和胚胎发育过程中初级纤毛的形成。
Centrosomes play significant central roles during reproduction, cell division, embryo development and stem cell biology, and a wealth of new information has been accumulated during the past decade that spans molecular details and newly discovered functions/dysfunctions for specific centrosome proteins in various cellular activities. The present review will focus on the current state of knowledge on the role of germ cell centrosomes during fertilization, formation of the zygote centrosome, centrosome duplication and separation during first embryonic cell division, and asymmetric cell divisions during cell differentiation and subsequent embryo development. It will also address asymmetric cell division in stem cells and formation of the primary cilium during embryo development.