Cl- replacement alters the ventilatory response to central chemoreceptor stimulation.
Cl- replacement alters the ventilatory response to central chemoreceptor stimulation.
复制标题
Cl-替代改变了对中枢化学感受器刺激的通气反应。
DOI：
10.1152/jappl.1993.74.1.280
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Adams,JM
中科院分区：
文献类型：
--
作者：
Davidson,TL;Sullivan,MP;Swanson,KE;Adams,JM
为了确定是否脑脊液（CSF）Cl-有一个作用，在确定刺激的中央呼吸化学感受器的条件下，恒定的CSF pH值，CO2，和HCO 3-浓度，腹侧髓表面的麻醉大鼠灌注模拟CSF的各种离子组成和pH值。四模拟CSF灌注液：两个正常的pH值控制灌注和两个酸性溶液。一种酸性灌注液以传统方式通过用Cl-替代HCO 3-来配制。第二种酸性灌注液和一种正常pH对照灌注液中约15%的Cl-被羟乙基磺酸盐（一种不渗透的强阴离子）取代。当两种酸性溶液灌注在腹侧髓质，一致较大的增加潮气量和分钟通气量观察到与羟乙基磺酸盐的酸性溶液，尽管相同的pH值和PCO 2的条件。两种酸性灌注的不相等的稀释作用表明，Cl-转运可能是决定中枢呼吸化学感受器刺激的一个因素。
To determine whether cerebrospinal fluid (CSF) Cl- has a role in determining the stimulus to the central respiratory chemoreceptors under conditions of constant CSF pH, CO2, and HCO3- concentrations, the ventral medullary surface of the anesthetized rat was perfused with mock CSF of various ion composition and pH. Four mock CSF perfusates were used: two normal pH control perfusions and two acidic solutions. One acidic perfusate was formulated in the traditional manner by substituting Cl- for HCO3-. The second acidic perfusate, and one of the normal pH control perfusates, had approximately 15% of the Cl- replaced with isethionate, an impermeant strong anion. When the two acidic solutions were perfused over the ventral medulla, consistently larger increases in both tidal volume and minute ventilation were observed with the isethionate-containing acidic solution, despite conditions of identical pH and PCO2. The unequal ventilatory effects of the two acidic perfusions suggest that Cl- transport may be a factor determining the stimulus to the central respiratory chemoreceptors.