Hereditary acholuric jaundice - In a new mutant strain of rats
Hereditary acholuric jaundice - In a new mutant strain of rats
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DOI：
10.1093/oxfordjournals.jhered.a104478
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发表时间：
1938-04-01
影响因子：
3.1
通讯作者：
Gunn, CH
中科院分区：
文献类型：
--
作者：
Gunn, CH
1934年发现的突变体，由于其系统中胆色素的异常量而显得相对黄色。当一个正常的混血儿（雌性）生下具有黄疸遗传体质的年轻人时，出生时是正常的，并在接下来的12小时内变得黄疸。左右黄疸母鼠的基因型黄疸后代在出生时为黄色。杂交大鼠表现正常，但其中50%的红细胞脆性增加和网织红细胞增多。脾切除术对这个缺陷没有反应。新的证据被发现的单基因理论的综合征。5代人类谱系以轮廓示出。
Discovered in 1934, the mutant appears relatively yellow owing to an abnormal amount of bile pigment in its system. Young with the genetic constitution for jaundice, when born to a normal hybrid [female], were normal at birth and became jaundiced in the course of the next 12 hrs. or so. Genotypically jaundiced progeny of jaundiced dams were yellow at birth. Hybrid rats appear normal but 50% of them showed an increased fragility of the erythrocytes and a reticulocytosis. The defect does not respond to splenectomy. New evidence was found for the single gene theory of a syndrome. A 5-generation human pedigree is shown in outline.