Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in children
Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in children
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DOI：
10.1016/j.numecd.2020.11.025
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发表时间：
2021-03-10
影响因子：
3.9
通讯作者：
Baroni, Marco G.
中科院分区：
文献类型：
--
作者：
Barchetta, Ilaria;Bertoccini, Laura;Baroni, Marco G.
背景和目的：神经降压素（NT）是一种摄入脂肪后释放的肠肽，可调节食欲并促进脂质吸收。其稳定的前体神经降压素原 (pro-NT) 血浆水平升高与成人 2 型糖尿病、肥胖和心血管死亡率相关；没有关于儿童中 pro-NT 和代谢疾病的数据。该研究的目的是评估血浆 pro-NT 与儿童肥胖的关系，并测试高 pro-NT 是否与以后生活中代谢障碍的发展相关。方法和结果：在这项纵向回顾性研究中，我们研究了 151 名在意大利卡利亚里大学接受代谢评估的超重/肥胖儿童。还对 46 名正常体重、年龄、性别相当的正常体重儿童进行了评估，选择作为参考组。在基线时，超重/肥胖和正常体重儿童之间的 pro-NT 具有可比性，并且与年龄 (p < 0.001)、甘油三酯 (p < 0.001) 呈正相关，与 HDL 水平呈负相关 (p = 0.008)。调整多个混杂因素后，血浆 pro-NT 与高甘油三酯相关，OR = 5.9（95%CI：1.24-28.1；p = 0.026）。在 6.5 年的随访中，高基础 pro-NT 与受损的 β 细胞功能相关，以补偿胰岛素抵抗（处置指数：r = -0.19，p = 0.035）和预测的体重增加，如标准差分数 BMI 的百分比变化所示（最高三分位中位数（95% CI）= +20.8（+4.9-+27.5）%），与年龄、性别、甘油三酯和胰岛素抵抗（标准化 beta = 0.24；p = 0.036）。结论：儿童中 NT 前体水平升高与以后的体重增加显着相关，并且可能代表肥胖时易受代谢损害的标志。 (C) 2020 意大利糖尿病学会、意大利动脉粥样硬化研究学会、意大利人类营养学会以及费德里科二世大学临床医学和外科系。由 Elsevier B.V. 出版。保留所有权利。
Background and aims: Neurotensin (NT) is an intestinal peptide released after fat ingestion, which regulates appetite and facilitates lipid absorption. Elevated plasma levels of its stable precursor pro-neurotensin (pro-NT) are associated with type 2 diabetes, obesity and cardiovascular mortality in adult populations; no data on pro-NT and metabolic disease are available in children.Aim of the study was to evaluate plasma pro-NT in relation to the presence of obesity in children, and to test if high pro-NT associates with the development of metabolic impairment later in life.Methods and results: For this longitudinal retrospective study, we studied 151 overweight/obese children undergoing metabolic evaluations at University of Cagliari, Italy. Pro-NT was also assessed in 46 normal-weight, age-, sex-comparable normal-weight children, selected as a reference group.At the baseline, pro-NT was comparable between overweight/obese and normal-weight children and correlated positively with age (p < 0.001), triglycerides (p < 0.001) and inversely with HDL levels (p = 0.008). Plasma pro-NT associated with high triglycerides with OR = 5.9 (95%CI: 1.24-28.1; p = 0.026) after adjustment for multiple confounders. At the 6.5-year follow-up, high basal pro-NT associated with impaired beta-cell function to compensate for insulin-resistance (disposition index: r = -0.19, p = 0.035) and predicted bodyweight increase, as indicated by percentage change of standard deviation score BMI (median(95%CI) = +20.8(+4.9-+27.5)% in the highest tertile), independently from age, sex, triglycerides and insulin-resistance (standardized beta = 0.24; p = 0.036).Conclusions: Elevated pro-NT levels in children are significantly associated with weight gain later in life and may represent a marker of susceptibility to metabolic impairment in presence of obesity. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.