Robinson and madison have published no data on whether polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve.
Robinson and madison have published no data on whether polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve.
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DOI：
10.1002/jnr.23849
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发表时间：
2017-03
影响因子：
4.2
通讯作者：
Mikesh M
中科院分区：
文献类型：
--
作者：
Bittner GD;Sengelaub DR;Trevino RC;Ghergherehchi CL;Mikesh M
据报道，聚乙二醇（PEG）融合技术可以在横断或消融哺乳动物坐骨神经部分后的几天到几周内快速、有效和永久地恢复失去的行为功能，后者的损伤最好通过可行的坐骨神经的同种异体移植来修复。 PEG融合必须导致幸存的远端、近端和/或移植运动和感觉轴突的不适当融合，这些轴突具有与其近端轴突连接不同的起源肌肉和/或感受野。不知何故，这些不适当的 PEG 融合轴突不表现出华勒变性和/或轴突通过生长（至少几周后）重新支配靶组织，必定是 3 天至 8 周内广泛行为恢复的原因。我们、Robinson 和 Madison 都尚未发表任何有关 PNS 神经成功 PEG 融合后运动神经元重新神经支配准确性的数据。关于轴突特异性和可塑性的细胞/分子机制的准确数据对于理解 PEG 融合技术成功的原因非常重要，该技术可能会在创伤性 PNS 神经损伤的治疗中产生范式转变。
Polyethylene glycol (PEG)-fusion technologies have been reported to rapidly, effectively, and permanently restore lost behavioral functions within days to several weeks after transecting or ablating portions of mammalian sciatic nerves, the latter injuries best repaired by allografts of viable sciatic nerves. PEG-fusion must result in inappropriate fusions of surviving distal, proximal and/or graft motor and sensory axons having different muscles of origin and/or receptive fields than their proximal axonal connections. Somehow, these inappropriately PEG-fused axons that do not exhibit Wallerian degeneration and/or axons re-innervating target tissues by outgrowth (after at least several weeks) must be responsible for the extensive behavioral recovery at 3 days to 8 weeks. Neither we nor Robinson and Madison have yet published any data on the accuracy of any reinnervation of motoneurons after successful PEG-fusion of a PNS nerve. Accurate data on cellular/molecular mechanisms of axonal specificity and plasticity are important to understand the reasons for the success of PEG-fusion technologies that could produce a paradigm shift in the treatment of traumatic PNS nerve injuries.