Bacteroides gingivalis fimbriae stimulate production of thymocyte-activating factor by human gingival fibroblasts
Bacteroides gingivalis fimbriae stimulate production of thymocyte-activating factor by human gingival fibroblasts
复制标题
牙龈拟杆菌菌毛刺激人牙龈成纤维细胞产生胸腺细胞激活因子
作者：
S. Hanazawa;Kimiharu Hirose;Yoshihiro Ohmori;Shigeru Amano;S. Kitano
在上一份报告中（Y。Ohmori，S. Hanazawa，S. Amano，T. Miyoshi，K. Hirose和S.北野，感染。Immun. 55：947-954，1987），我们表明人牙龈成纤维细胞自发产生胸腺细胞活化因子（FTAF），其刺激有丝分裂原诱导的胸腺细胞增殖。在本研究中，我们研究了牙龈拟杆菌菌毛对细胞产生FTAF的影响，因为菌毛可能参与了生物体与牙周组织的附着。我们在这里表明，菌毛结合的细胞，这可能随后导致刺激FTAF生产的细胞。
In a previous report (Y. Ohmori, S. Hanazawa, S. Amano, T. Miyoshi, K. Hirose, and S. Kitano, infect. Immun. 55:947-954, 1987), we showed that human gingival fibroblasts spontaneously produce thymocyte-activating factor (FTAF), which stimulates mitogen-induced thymocyte proliferation. In the present study, we examined the effect of Bacteroides gingivalis fimbriae on FTAF production by the cells, because the fimbriae may be involved in attachment of the organism to periodontal tissues. We show here that the fimbriae bind to the cells, which may subsequently lead to the stimulation of FTAF production by the cells.