Ubiquitin-immunoreactive skein-like inclusions in the neostriatum are not restricted to amyotrophic lateral sclerosis, but are rather aging-related structures
Ubiquitin-immunoreactive skein-like inclusions in the neostriatum are not restricted to amyotrophic lateral sclerosis, but are rather aging-related structures
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DOI：
10.1007/s004010051191
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发表时间：
2000-07-01
影响因子：
12.7
通讯作者：
Iwaki, T
中科院分区：
文献类型：
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作者：
Kawashima, T;Furuta, A;Iwaki, T
我们研究了正常人和不同神经退行性疾病患者的新纹状体和脊髓中存在的泛素免疫反应性绞样包涵体（SLI）。在正常人和各种神经退行性疾病患者的新纹状体中观察到泛素免疫反应性SLI。特别是SLI常见于正常老年人和某些神经退行性疾病，如进行性核上性麻痹和强直性肌营养不良。相反，皮克病和多系统萎缩病例中SLI的发生率有下降趋势。另一方面，脊髓前角的SLI在肌萎缩侧索硬化症的病例中被检测到，但在其他神经退行性疾病的病例中没有检测到。新纹状体中的SLI也可使用磷钨酸-苏木精和Gomori三色染色来识别。泛素免疫电镜显示，在新纹状体的SLI对应的纤维束。新纹状体SLI的这些特征与Kojima和Ogawa于1974年首次描述的尾状核大神经元胞浆内杆状包涵体（intracytoplasmic rod-like inclusions，RLI）的特征十分相似。我们的研究结果表明，SLI在新纹状体的泛素相关的结构，其发生率增加的老化，并不经常伴随着几种神经退行性疾病，并至少有一些RLI相同。
We examined the presence of ubiquitin-immunoreactive skein-like inclusions (SLI) in the neostriatum and spinal cord in normal individuals and patients with different neurodegenerative diseases. Ubiquitin-immunoreactive SLI in the neostriatum were observed both in the normal individuals and in the patients with a variety of neurodegenerative diseases. In particular, SLI were frequently seen in normal aged subjects and certain neurodegenerative diseases, such as progressive supranuclear palsy and myotonic dystrophy. In contrast, the occurrence rate of SLI in cases with Pick's disease and multiple system atrophy tended to decrease. On the other hand, SLI in the spinal anterior horn were detected in cases of amyotrophic lateral sclerosis, but not in any cases with other neurodegenerative diseases. SLI in the neostriatum were also identifiable using phosphotungstic acid-hematoxylin and Gomori trichrome staining. Ubiquitin immunoelectron microscopy demonstrated that the SLI in the neostriatum corresponded to bundles of filaments. These features of SLI in the neostriatum were quite similar to those of intracytoplasmic rod-like inclusions (RLI) in the large neurons of caudate nucleus, which were first described by Kojima and Ogawa in 1974. Our findings indicate that SLI in the neostriatum are ubiquitin-related structures whose occurrence increases by aging, and less frequently accompany several neurodegenerative diseases, and are identical to at least some RLI.