Associations Between Hormonal Biomarkers and Cognitive, Motor, and Language Developmental Status in Very Low Birth Weight Infants.
Associations Between Hormonal Biomarkers and Cognitive, Motor, and Language Developmental Status in Very Low Birth Weight Infants.
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DOI：
10.1097/nnr.0000000000000228
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发表时间：
2017
期刊：
影响因子：
2.5
通讯作者：
Carlo WA
中科院分区：
文献类型：
--
作者：
Cho J;Holditch-Davis D;Su X;Phillips V;Biasini F;Carlo WA
男婴比女婴更容易出现健康问题和发育迟缓。基于大脑发育和社会关系的性别差异理论，我们探讨了睾酮和皮质醇水平与极低出生体重儿（VLBW）婴儿认知、运动和语言发育（“婴儿发育”）之间的关系，控制了母婴互动、母婴特征和出生后唾液收集天数。从美国东南部一家三级医疗中心的新生儿重症监护室共招募了62对母亲-极低出生体重婴儿。通过婴儿病历回顾、生化测量、观察母婴互动和标准问卷收集数据。在6个月校正年龄（CA）时评估婴儿发育，并在3个月和6个月CA时观察母婴相互作用。一般线性回归与单独分析每个婴儿的性别表明，高睾酮水平与控制母婴互动和其他协变量后，男性婴儿的语言发育呈正相关，而高皮质醇水平与控制母婴互动后，女性婴儿的运动发育呈负相关。类固醇激素水平可能是评估婴儿发育的更基本的因素，而不是婴儿性别或6个月CA时的母婴相互作用。
Male infants are more prone to health problems and developmental delays than female infants. Based on theories of gender differences in brain development and social relationships, we explored associations between testosterone and cortisol levels with infant cognitive, motor, and language development (“infant development”) in very low birthweight (VLBW) infants, controlling for mother–infant interactions, characteristics of mothers and infants, and days of saliva collection after birth. A total of 62 mother–VLBW infant pairs were recruited from the newborn intensive care unit of a tertiary medical center in the Southeast U.S. Data were collected through infant medical record review, biochemical measurement, observation of mother–infant interactions, and standard questionnaires. Infant development was assessed at 6 months corrected age (CA) and mother–infant interactions were observed at 3 and 6 months CA. General linear regression with separate analyses for each infant gender showed that high testosterone levels were positively associated with language development of male infants after controlling for mother–infant interactions and other covariates, whereas high cortisol levels were negatively associated with motor development of female infants after controlling for mother–infant interactions. Steroid hormonal levels may well be more fundamental factors for assessing infant development than infant gender or mother–infant interactions at 6 months CA.