Hindlimb endpoint forces predict movement direction evoked by intraspinal microstimulation in cats.
Hindlimb endpoint forces predict movement direction evoked by intraspinal microstimulation in cats.
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DOI：
10.1109/tnsre.2009.2023295
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Grill WM
中科院分区：
文献类型：
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作者：
Lemay MA;Grasse D;Grill WM
我们测量了猫的后爪产生的力量，通过微刺激腰椎脊髓和运动所产生的这些力量。我们还测量了两个椎管内位点的共同和顺序激活所产生的力和运动。在九个肢体配置与爪连接到力传感器测量等距力响应。将在不同肢体配置处引起的主动力总结为代表在整个工作空间中在爪处产生的力的矢状面分量的模式。力模式分为与股骨固定相同的不同类型。两个脊髓部位同时激活期间的反应总是类似于两个部位之一激活的反应，即，赢家通吃，我们没有观察到在慢性脊柱动物中报告的每个部位单独激活所产生的力的矢量总和。每个部位的激活所产生的运动与力的方向一致，并且可以通过改变各个部位的激活顺序来产生不同的运动。我们的研究结果强调了在去大脑动物的椎管内微刺激过程中没有矢量求和现象，以及在运动过程中等长力方向的保留。
We measured the forces produced at the cat’s hindpaw by microstimulation of the lumbar spinal cord and the movements resulting from those forces. We also measured the forces and movements produced by co- and sequential activation of two intraspinal sites. Isometric force responses were measured at nine limb configurations with the paw attached to a force transducer. The active forces elicited at different limb configurations were summarized as patterns representing the sagittal plane component of the forces produced at the paw throughout the workspace. The force patterns divided into the same distinct types found with the femur fixed. The responses during simultaneous activation of two spinal sites always resembled the response for activation of one of the two sites, i.e., winner-take-all, and we did not observe vectorial summation of the forces produced by activation of each site individually as reported in chronic spinal animals. The movements produced by activation of each of the sites were consistent with the force orientations, and different movements could be created by varying the sequence of activation of individual sites. Our results highlight the absence of a vectorial summation phenomenon during intraspinal microstimulation in decerebrate animals, and the preservation during movement of the orientation of isometric forces.