DYNAMICS OF ENTEROHEPATIC CIRCULATION OF BILE-ACIDS - POSTPRANDIAL SERUM CONCENTRATIONS OF CONJUGATES OF CHOLIC ACID IN HEALTH, CHOLECYSTECTOMIZED PATIENTS, AND PATIENTS WITH BILE-ACID MALABSORPTION
DYNAMICS OF ENTEROHEPATIC CIRCULATION OF BILE-ACIDS - POSTPRANDIAL SERUM CONCENTRATIONS OF CONJUGATES OF CHOLIC ACID IN HEALTH, CHOLECYSTECTOMIZED PATIENTS, AND PATIENTS WITH BILE-ACID MALABSORPTION
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DOI：
10.1056/nejm197410032911401
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发表时间：
1974-01-01
影响因子：
158.5
通讯作者：
HOFMANN, AF
中科院分区：
文献类型：
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作者：
LARUSSO, NF;KORMAN, MG;HOFMANN, AF
用放射免疫法测定了三种液体餐对血清胆酸偶联物水平的影响。在8名健康受试者中，这些胆汁酸在每餐后90至120分钟达到峰值，并在4小时后回到基线。这种模式与饮食有关，因为在经历22小时禁食的4名受试者中，这些值保持在基线上。在5例胆囊切除术患者中，胆酸缀合物在第一餐后升高至较低的最大值，然后全天保持升高，在晚餐后14小时回到基线。在6例胆汁酸吸收不良（回肠切除后）患者中，第一餐后胆汁酸的增加小于健康者；在午餐后几乎检测不到增加，在晚餐后发生。在肝功能正常的受试者中，餐后胆酸偶联物似乎表明胆汁酸的肠肝循环动力学；胆汁酸的水平部分取决于肠道对胆汁酸的吸收，而肠道对胆汁酸的吸收又取决于胆囊收缩和有效的回肠吸收。[J] .中华医学杂志，2004(5):387 - 398。
The effect of three liquid meals on the serum level of conjugates of cholic acid was determined by radioimmunoassay. In eight healthy subjects, these bile acids peaked 90 to 120 minutes after each meal, and returned to base line by four hours. This pattern was meal related because the values remained at base line in four subjects undergoing a 22-hour fast. In five patients with cholecystectomy, conjugates of cholic acid increased to lower maxima after the first meal, and then remained elevated throughout the day, returning to base line 14 hours after the evening meal.In six patients with bile acid malabsorption (after ileal resection), the postprandial increase after the first meal was smaller than in health; an increase was barely detectable after the mid-day meal and occurred after the evening meal. In subjects with normal liver function, postprandial conjugates of cholic acid appear to indicate the dynamics of the enterohepatic circulation of bile acids; the level depends in part on intestinal absorption of these bile acids, which depends in turn on gallbladder contraction and efficient ileal absorption. (N Engl J Med 291:689–692, 1974)