Early NMDA receptor-driven waves of activity in the developing neocortex: physiological or pathological network oscillations?
Early NMDA receptor-driven waves of activity in the developing neocortex: physiological or pathological network oscillations?
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DOI：
10.1113/jphysiol.2009.178798
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发表时间：
2010-01-01
影响因子：
5.5
通讯作者：
Cossart, Rosa
中科院分区：
文献类型：
--
作者：
Allene, Camille;Cossart, Rosa
在发育中的皮层结构中已经描述了几种相干活动模式，从而为网络成熟提供了一个一般框架。在电路和细胞水平上详细及时地描述网络模式对于理解大脑发育过程中发生的致病过程至关重要。这种模式序列的表达时间表的扰动很可能影响网络的成熟。这篇综述主要集中在发育中的新皮层结构的连贯活动模式的成熟。它强调的内在和突触的细胞特性是独特的未成熟的新皮层，特别是细胞外谷氨酸在控制网络兴奋性和触发同步网络波的活动中发挥的关键作用。
Several patterns of coherent activity have been described in developing cortical structures, thus providing a general framework for network maturation. A detailed timely description of network patterns at circuit and cell levels is essential for the understanding of pathogenic processes occurring during brain development. Disturbances in the expression timetable of this pattern sequence are very likely to affect network maturation. This review focuses on the maturation of coherent activity patterns in developing neocortical structures. It emphasizes the intrinsic and synaptic cellular properties that are unique to the immature neocortex and, in particular, the critical role played by extracellular glutamate in controlling network excitability and triggering synchronous network waves of activity.