The role of acidic phosphoproteins in biomineralization.
The role of acidic phosphoproteins in biomineralization.
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DOI：
10.3109/03008207.2013.867336
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发表时间：
2014-01
影响因子：
2.9
通讯作者：
Alvares K
中科院分区：
文献类型：
--
作者：
Alvares K
生物矿化是生物体在细胞外基质中存款矿物质的过程。在自然界中，几乎50%的生物矿物是含钙矿物。除了钙之外，我们还发现了由二氧化硅和磁铁矿形成的生物矿物。含钙的生物矿物可以是磷酸钙，如在脊椎动物中发现的磷灰石，或者是碳酸钙，如在许多无脊椎动物中发现的方解石和文石。由于所有的生物矿化都是基质介导的，因此了解所涉及的蛋白质的性质对于阐明其机制至关重要。本文将讨论一些蛋白质参与的过程中涉及钙的生物矿化。两种蛋白质，牙本质基质蛋白1和牙本质磷蛋白（Phosphophoryn）将作为脊椎动物系统的模型，另外两种蛋白质-P16和phosphodontin将作为无脊椎动物系统的模型。
Biomineralization is the process by which living organisms deposit mineral in the extracellular matrix. In nature, almost 50% of biominerals are calcium-bearing minerals. In addition to calcium, we also find biominerals formed from silica and magnetite. Calcium containing biominerals could be either calcium phosphate as in apatite found in vertebrates or calcium carbonate as in calcite and aragonite found in many invertebrates. Since all biomineralization is matrix mediated, an understanding of the nature of the proteins involved is essential in elucidating its mechanism. This review will discuss some of the proteins involved in the process of biomineralization involving calcium. Two proteins, dentin matrix protein 1 and dentin phosphoprotein (Phosphophoryn) will serve as models for the vertebrate system, and two others - P16 and phosphodontin will serve as models for the invertebrate system.