Spontaneous brain activity relates to autonomic arousal.
Spontaneous brain activity relates to autonomic arousal.
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DOI：
10.1523/jneurosci.1172-12.2012
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发表时间：
2012-08-15
期刊：
影响因子：
--
通讯作者：
Hof PR
中科院分区：
文献类型：
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作者：
Fan J;Xu P;Van Dam NT;Eilam-Stock T;Gu X;Luo YJ;Hof PR
虽然已经提出了大脑静息态网络（RSN）的可能来源和功能，但大多数证据依赖于循环逻辑和反向推理。我们建议，自主觉醒提供了一个客观的指标，心理生理状态在休息，也可以作为一个驱动源的活动和连接的RSN。利用功能磁共振成像和皮肤电导同时记录人体静息状态下的血氧水平依赖（BOLD）信号，发现RSN关键节点BOLD信号的自发波动与非特异性皮肤电导反应的变化相关，而非特异性皮肤电导反应是反映自主神经唤醒的敏感心理生理指标。我们的研究结果提供了一个重要的作用，自主神经系统的大脑自发活动在“休息”的证据。
Although possible sources and functions of the resting state networks (RSN) of the brain have been proposed, most evidence relies on circular logic and reverse inference. We propose that autonomic arousal provides an objective index of psychophysiological states during rest that may also function as a driving source of the activity and connectivity of RSN. Recording blood oxygenation level-dependent (BOLD) signal using functional magnetic resonance imaging and skin conductance simultaneously during rest in human subjects, we found that the spontaneous fluctuations of BOLD signals in key nodes of RSN are associated with changes in non-specific skin conductance response, a sensitive psychophysiological index of autonomic arousal. Our findings provide evidence of an important role for the autonomic nervous system to the spontaneous activity of the brain during ‘rest’.