Cancer cell metabolism: one hallmark, many faces.
Cancer cell metabolism: one hallmark, many faces.
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DOI：
10.1158/2159-8290.cd-12-0345
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发表时间：
2012-10
期刊：
影响因子：
28.2
通讯作者：
Sabatini DM
中科院分区：
文献类型：
--
作者：
Cantor JR;Sabatini DM
癌细胞必须重新连接细胞代谢，以满足生长和增殖的需要。虽然许多代谢变化在很大程度上类似于正常增殖细胞的代谢变化，但在癌症中，它们是由遗传损伤和非遗传因素(如肿瘤微环境)的组合异常驱动的。然而，单一的肿瘤代谢改变模型并不能描述支持细胞生长的代谢变化的总和。相反，癌细胞代谢程序中这种变化的多样性可以决定以什么方式驱动增殖性重新连接，也可以在细胞的新陈代谢依赖中传递异质性。更好地了解这种异质性可能有助于开发和优化针对肿瘤新陈代谢的治疗策略。
Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. While many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly driven in cancer by a combination of genetic lesions and non-genetic factors such as the tumor microenvironment. However, a single model of altered tumor metabolism does not describe the sum of metabolic changes that can support cell growth. Instead, the diversity of such changes within the metabolic program of a cancer cell can dictate by what means proliferative rewiring is driven, and can also impart heterogeneity in the metabolic dependencies of the cell. A better understanding of this heterogeneity may enable the development and optimization of therapeutic strategies that target tumor metabolism.