Rhabdomyolysis Caused by Candida parapsilosis in a Patient with Acute Myeloid Leukemia after Bone Marrow Transplantation.
Rhabdomyolysis Caused by Candida parapsilosis in a Patient with Acute Myeloid Leukemia after Bone Marrow Transplantation.
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急性髓系白血病患者骨髓移植后由近平滑念珠菌引起的横纹肌溶解症。
DOI：
10.2169/internalmedicine.54.4136
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发表时间：
2015
影响因子：
1.2
通讯作者：
H. Minami
中科院分区：
文献类型：
--
作者：
Seiji Kakiuchi;K. Yakushijin;Katsuya Yamamoto;H. Tomioka;Yumiko Inui;A. Okamura;S. Kawamoto;Y. Minami;T. Murayama;M. Ito;H. Matsuoka;H. Minami
横纹肌溶解症的特点是肌酸激酶 (CK) 水平显着升高和肌红蛋白尿，从而导致肾功能障碍。多种病毒或细菌都可能是病因，但很少有报道称真菌病是横纹肌溶解症的原因。在本报告中，我们描述了一名患有急性髓系白血病的青少年男性，他接受了同种异体骨髓移植，此后几乎同时出现了横纹肌溶解症和近平滑念珠菌真菌血症。近平滑念珠菌治疗后，转氨酶和 CK 水平均显着下降。该病例说明近平滑念珠菌感染可能是免疫功能低下患者横纹肌溶解症的病原体。
Rhabdomyolysis is characterized by a marked elevation of the creatine kinase (CK) levels and myoglobinuria, thus leading to renal dysfunction. Various viruses or bacteria can be etiologic agents, but mycosis has only rarely been reported to be a cause of rhabdomyolysis. In this report, we describe an adolescent male with acute myeloid leukemia who underwent allogeneic bone marrow transplantation and thereafter developed rhabdomyolysis and Candida parapsilosis fungemia almost at the same time. Following treatment for C. parapsilosis, the transaminase and CK levels both satisfactorily decreased. This case illustrates that C. parapsilosis infection may be a causative agent of rhabdomyolysis in immunocompromised patients.