The Apathy Inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment
The Apathy Inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment
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DOI：
10.1002/gps.755
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发表时间：
2002-12-01
影响因子：
4
通讯作者：
Bedoucha, P
中科院分区：
文献类型：
--
作者：
Robert, PH;Clairet, S;Bedoucha, P
目的本研究旨在建立冷漠量表（IA）的效度和信度。IA是一种评估整体冷漠和情绪迟钝、缺乏主动性和缺乏兴趣的单独评估量表。方法从患者或护理人员处获取IA信息。我们使用IA评估了115名受试者，包括19名健康老年人，24名轻度认知障碍（MCI）患者，12名帕金森病（PD）患者和60名阿尔茨海默病（AD）患者。结果内部一致性、项目信度和评间信度较高。一项重测信度研究表明，护理者对IA问题的回答在短时间内是稳定的。一项同时进行的效度研究表明，IA与神经精神病学量表冷漠域一样有效地评估冷漠。在基于照顾者的评估中，AD受试者在整体冷漠得分和缺乏兴趣维度上的得分均显著高于对照组。当根据冷漠诊断标准对AD患者进行细分时，冷漠患者的得分明显高于非冷漠患者。在基于患者的评估中，AD组、MCI组和对照组之间没有发现差异。在基于患者的评估中，PD组的得分仅高于对照组。结果还表明，AD患者对自己情绪钝化的认识较差，缺乏主动性。结论IA是一种可靠的评估老年痴呆和非痴呆受试者麻木综合征的几个维度，以及受试者对这些症状的认识的方法。版权所有:John Wiley Sons, Ltd。
Objective This study was designed to establish the validity and reliability of the apathy inventory (IA), a rating scale for global assessment of apathy and separate assessment of emotional blunting, lack of initiative, and lack of interest.Method Information for the IA can be obtained from the patient or from a caregiver. We evaluated 115 subjects using the IA, consisting of 19 healthy elderly subjects, 24 patients with Mild Cognitive Impairment (MCI), 12 subjects with Parkinson's disease (PD) and 60 subjects with Alzheimer's disease (AD).Results Internal consistency, item reliability, and between-rater reliability were high. A test-retest reliability study demonstrated that caregiver responses to IA questions were stable over short intervals. A concurrent validity study showed that the IA assesses apathy as effectively as the Neuro Psychiatric Inventory apathy domain. In the caregiver-based evaluation, AD subjects had significantly higher scores than controls, both for global apathy score and for the lack of interest dimension. When the AD patients were subdivided according to diagnostic criteria for apathy, apathetic patients had significantly higher scores than non apathetic patients. With the patient-based evaluations, no differences were found among the AD, MCI and control groups. The scores in the patient-based evaluations were only higher for the PD group versus the control subjects. The results also indicated that AD patients had poor awareness of their emotional blunting and lack of initiative.Conclusions The IA is a reliable method for assessing in demented and non-demented elderly subjects several dimensions of the apathetic syndrome, and also the subject's awareness of these symptoms. Copyright (C) 2002 John Wiley Sons, Ltd.