Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans
Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans
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DOI：
10.1034/j.1600-0765.2002.01001.x
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发表时间：
2002-08-01
影响因子：
3.5
通讯作者：
Kenney, EB
中科院分区：
文献类型：
--
作者：
Camargo, PM;Lekovic, V;Kenney, EB
背景资料：富血小板血浆（PRP）、牛多孔骨矿物质（BPBM）和引导组织再生（GTR）的组合已被证明可有效促进骨内缺损中牙周再生的临床体征。作为在最初的尝试，以澄清仙人掌的三个治疗组件所发挥的作用，本研究进行比较两个再生技术的临床效果骨内缺损在人类：PRP/BPBM/GTR与GTR.Material和方法相结合：18例患者参加了这项研究。使用裂口设计，用聚乳酸制成的可吸收膜进行GTR或PRP/BPBM/GTR组合手术治疗邻间骨缺损。口袋深度，附件水平和缺陷填充的变化，揭示了6个月的再入surgery evaluated.Results：两种治疗方式导致显着的口袋深度减少和临床附件增益相比，基线值。PRP/BPBM/GTR组颊侧和舌侧的囊袋深度分别减少4.98 +/- 0.96 mm和4.93 +/- 0.92 mm，GTR组颊侧和舌侧的囊袋深度分别减少3.62 +/- 0.81 mm和3.54 +/- 0.88 mm。观察到PRP/BPBM/GTR组的临床附着增加在颊侧为4.37 +/-1.31 mm，在舌侧为4.28 +/- 1.33 mm，GTR组的颊侧为2.62 +/- 1.23 mm，在舌侧为2.44 +/- 1.21 mm。PRP/BPBM/GTR组的颊侧和舌侧观察到的缺损填充量分别为4.78 +/- 1.26 mm和4.66 +/- 1.32 mm，GTR组的颊侧和舌侧分别为2.31 +/- 0.76 mm和2.26 +/- 0.81 mm。两组之间的所有差异均具有统计学显著性，有利于PRP/BPBM/GTR组。结论：本研究的结果表明，PRP和BPBM在促进严重牙周炎患者骨内缺损的临床解决方面为GTR提供了额外的再生效果。
Background: A combination of platelet-rich plasma (PRP), bovine porous bone mineral (BPBM) and guided tissue regeneration (GTR) has been shown to be effective in promoting clinical signs of periodontal regeneration in intrabony defects. As in initial attempt to clarify the role played by cacti of the three treatment components, this study was performed to compare the clinical effectiveness of two regenerative techniques for intrabony defects in humans: a combination of PRP/BPBM/GTR vs. GTR.Material and methods: Eighteen patients participated in the study. Using a split-mouth design, interproximal bony defects were surgically treated with either an absorbable :membrane made of polylactic acid for GTR or a combination of PRP/BPBM/GTR. Changes in pocket depth, attachment level and defect fill as revealed by 6-month reentry surgeries were evaluated.Results: Both treatment modalities resulted in significant pocket depth reduction and clinical attachment gain as compared to baseline values. Pocket depth reduction was 4.98 +/- 0.96 mm on buccal and 4.93 +/- 0.92 mm on lingual sites of the PRP/BPBM/GTR group and 3.62 +/- 0.81 mm on buccal and 3.54 +/- 0.88 mm on lingual sites of the GTR group. The gain in clinical attachment observed was 4.37 +/- 1.31 mm on buccal and 4.28 +/- 1.33 mm on lingual sites of the PRP/BPBM/GTR group and 2.62 +/- 1.23 mm on buccal and 2.44 +/- 1.21 mm on lingual sites of the GTR group. The amount of defect fill observed was 4.78 +/- 1.26 mm on buccal and 4.66 +/- 1.32 mm on lingual sites of the PRP/BPBM/GTR group and 2.31 +/- 0.76 mm on buccal and 2.26 +/- 0.81 mm on lingual sites of the GTR group. All differences between the two groups were statistically significant in favor of the PRP/BPBM/GTR group,Conclusions: The results of this study suggest that PRP and BPBM provide an added regenerative effect to GTR in promoting the clinical resolution of intrabony defects on patients with severe periodontitis.