A novel method for controlling the quantity of mitomycin-C applied during filtering surgery for glaucoma.
A novel method for controlling the quantity of mitomycin-C applied during filtering surgery for glaucoma.
复制标题
一种控制青光眼滤过手术期间丝裂霉素 C 用量的新方法。
DOI：
10.1089/jop.1998.14.491
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Péchereau
中科院分区：
文献类型：
--
作者：
E. Mehel;M. Weber;L. Stork;A. Péchereau
在青光眼手术中，使用浸有丝裂霉素-C的海绵越来越普遍。文献中考虑了适当的抗生素浓度和暴露时间，但没有考虑使用的确切量或海绵的大小。本研究的目的是估计由不同外科医生制备的海绵中所含的丝裂霉素-C的量，并与Schirmer试验刻度（5 x 5 mm）中所用类型的涂抹器中的丝裂霉素-C的量进行比较。4名外科医生按照他们的常规方法各切割并准备了10块海绵用于术中使用。用10个Schirmer测试刻度进行相同的程序。将每个海绵和每个刻度浸入0.2 mg/ml丝裂霉素-C溶液中，并将每个中的抗生素量（微克）计算为湿重和干重之差。切割海绵中所含丝裂霉素-C的平均量（+/- SEM）为9.6 +/- 4.4 μ g（范围1.9-17.3），外科医生之间的差异具有统计学意义（p<0.0001）。Schirmer试验分级中抗生素的平均量为1.7 +/- 0.3 μ g（范围1.1-2.5），外科医生之间的差异无统计学意义（p=0.79）。青光眼手术准备的海绵中所含的丝裂霉素C的量对于给定的外科医生和外科医生之间是不同的。因此，应用于巩膜的剂量的变化可以解释丝裂霉素-C引起的某些并发症。使用Schirmer试验刻度提高了应用于巩膜的丝裂霉素-C的量的可预测性。
The use of a sponge impregnated with mitomycin-C is an increasingly common practice in glaucoma surgery. The appropriate antibiotic concentration and exposure time have been considered in the literature, but not the exact amount to be used or the size of the sponge. The purpose of this study was to estimate the quantity of mitomycin-C contained in sponges prepared by different surgeons as compared to that in applicators of the type used in Schirmer's test graduation (5 x 5 mm). Four surgeons each cut and prepared 10 sponges for intraoperative use according to their usual method. The same procedure was performed with 10 Schirmer's test graduations. Each sponge and each graduation was immersed in a solution of mitomycin-C 0.2 mg/ml, and the quantity of antibiotic (microg) in each was calculated as the difference between wet and dry weight. The mean quantity (+/- SEM) of mitomycin-C contained in cut sponges was 9.6 +/- 4.4 microg (range 1.9-17.3), and the differences between surgeons were statistically significant (p<0.0001). The mean quantity of antibiotic in Schirmer's test graduation was 1.7 +/- 0.3 microg (range 1.1-2.5), and the differences between surgeons were not statistically significant (p=0.79). The quantities of mitomycin-C contained in sponges prepared for glaucoma surgery differed for a given surgeon and between surgeons. Thus, variations in the doses applied to the sclera could account for certain complications due to mitomycin-C. The use of a Schirmer's test graduation improves predictability for the quantity of mitomycin-C applied to the sclera.
光神霉素、丝裂霉素、柔红霉素和博来霉素对人结膜下成纤维细胞附着和增殖的影响。
影响因子：
4.4
作者：
Lee,DA;Lee,TC;Cortes,AE;Kitada,S
通讯作者：
Kitada,S