Evaluation of the neuropharmacodynamics of paroxetine in vivo utilizing microdialysis.
Evaluation of the neuropharmacodynamics of paroxetine in vivo utilizing microdialysis.
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利用微透析评估帕罗西汀体内的神经药效学。
DOI：
10.1021/js970253z
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发表时间：
1997
影响因子：
3.8
通讯作者：
H. Karnes
中科院分区：
文献类型：
--
作者：
A. Ramaiya;J. H. Johnson;H. Karnes
在自由活动的清醒大鼠中评价了用于治疗抑郁症的选择性5-羟色胺再摄取抑制剂帕罗西汀对细胞外5-羟色胺水平的影响。微透析是一种监测细胞外神经递质水平的强大体内技术，用于监测帕罗西汀给药后大鼠大脑前外侧纹状体中5-羟色胺水平的基线变化，这是药物的神经药效学作用的量度。在腹膜内施用帕罗西汀（10 mg/kg）之前和之后进行微透析取样210 min和240 min。帕罗西汀导致微透析取样的前外侧纹状体细胞外5-羟色胺水平的统计学显著增加。本研究证明了微透析的效用，在清醒大鼠体内的神经药效学研究帕罗西汀。
The effect of paroxetine, a selective serotonin reuptake inhibitor used in the treatment of depression, on extracellular serotonin levels was evaluated in freely moving conscious rats. Microdialysis, a powerful in vivo technique to monitor the extracellular levels of neurotransmitters, was used to monitor the baseline changes in the levels of serotonin in rat brain anterior lateral striatum post paroxetine administration, which is a measure of the neuropharmacodynamic effect of the drug. Microdialysis sampling was performed for 210 min prior to and for 240 min after intraperitoneal administration of paroxetine (10 mg/kg). Paroxetine caused a statistically significant increase in the extracellular levels of serotonin in the anterior lateral striatum sampled by microdialysis. The present study demonstrates the utility of microdialysis for studying the in vivo neuropharmacodynamics of paroxetine in conscious rats.