LACK OF ORAL HSV-2 IN A COLLEGE-STUDENT POPULATION
LACK OF ORAL HSV-2 IN A COLLEGE-STUDENT POPULATION
复制标题
DOI：
10.1002/jmv.1890160309
复制
发表时间：
1985-01-01
影响因子：
12.7
通讯作者：
ZIMMERMAN, DH
中科院分区：
文献类型：
--
作者：
DOCHERTY, JJ;TRIMBLE, J;ZIMMERMAN, DH
生殖器单纯疱疹病毒1型（HSV-1）发病率高的人群，由于最有可能口腔生殖器接触，进行了检查，以确定口腔单纯疱疹病毒2型（HSV-2）感染的发病率。从43名大学生的口腔中分离出单纯疱疹病毒，其症状范围从嘴唇的单一病变（轻微不适）到严重的口腔疾病（全身受累），导致淋巴结病、寒战、出汗、肌痛和发热。从每个病例中分离的病毒通过血清中和鉴定，并使用（E）-5-（2-溴乙烯基）-2“-脱氧尿苷（BVDV）敏感性、单克隆抗体免疫荧光和限制性内切酶EcoRI消化病毒DNA分型为HSV-1或HSV-2。在所有情况下，分离株均为HSV-1。对头颈部分离株以及非大学患者的口腔样本进行的进一步鉴定和分型表明，所有这些也都是HSV-1。因此，虽然HSV-1似乎很容易在这组个体中传播到生殖器，但HSV-2传播到口腔可能并不常见，即使临床病史显示这些患者中有几个人参与了口腔-生殖器接触。
A population of individuals with a high incidence of genital herpes simplex virus type 1 (HSV-1), due most likely to oro-genital contact, was examined to determine the incidence of oral herpes simplex virus type 2 (HSV-2) infection. Herpes simplex virus was isolated from the oral cavity of 43 college students whose symptoms ranged from singular lesions of the lips with minimal discomfort to severe oral disease with systemic involvement resulting in lymphadenopathy, chills, sweat, myalgia, and fever. The virus isolated from each case was identified by serum neutralization and typed as HSV-1 or HSV-2 using (E)-5-(2-bromovinyl)-2''-deoxyuridine (BVDU) sensitivity, monoclonal antibody immunofluorescence, and restriction endonuclease EcoRI digestion of viral DNA. In every instance the isolate was HSV-1. Additional identification and typing of head and neck isolates as well as oral samples from nonuniversity patients demonstrated that all were also HSV-1. Therefore, while HSV-1 appears to be readily transmitted to the genitalia in this group of individuals, the transmission of HSV-2 to the oral cavity may not be as common, even though clinical histories revealed that several of these patients were engaging in oro-genital contact.