Adaptations of the male reproductive tract and the fate of spermatozoa following vasectomy in the rabbit, rhesus monkey, hamster and rat.
Adaptations of the male reproductive tract and the fate of spermatozoa following vasectomy in the rabbit, rhesus monkey, hamster and rat.
复制标题
兔子、恒河猴、仓鼠和大鼠输精管结扎术后雄性生殖道的适应和精子的命运。
作者：
J. Bedford
本文研究了家兔、恒河猴、大鼠和仓鼠输精管阻塞后输精管和附睾处理精子的方式。扩张的输精管和附睾的远端部分最初是明显的，但随后的物种和物种内的个人之间的反应各不相同。在家兔中，尽管32周时附睾中出现肉芽肿，但管道远端部分的扩张性似乎可确保其完整性至少24周。部分猴在术后5-6周出现输精管和/或附睾尾散在肉芽肿。这伴随着附睾尾部小但可触及的增大的消退。仓鼠附睾在手术后8周内发生肉眼可见肉芽肿的爆发，约30%的动物在梗阻部位显示终末囊肿。在大鼠中观察到的附睾肉芽肿不像在其他种属中那样频繁。精子的处置被认为是依赖于他们的摄入白细胞进入道通过肉芽肿和上皮样细胞内的终端输精管囊肿。一致观察到生精上皮的同侧破裂与肉芽肿和/或附睾头或附睾体扩张相关。大鼠和家兔单侧输精管切除术的效果表明，输精管切除术对这些动物的潜在生育力没有一般免疫介导的抑制作用。
The effects of vas obstruction in the rabbit rhesus monkey rat an d hamster were studied to determine the manner in which the vas deferens and epididymis dispose of spermatozoa after vasectomy. Distension of the vas and the distal portion of the epididymis was initially apparent but the subsequent response between species and individuals within species varied. In rabbits the distensibility of the distal portion of the tract appeared to insure its integrity for at least 24 weeks though granulomata appeared in the epididymis by 32 weeks. Some monkeys showed discrete granulomata in the vas deferens and/or cauda epididymis as early as 5-6 weeks after the operation. This was accompanied by a regression of a small though palpable enlargement of the cauda epididymis. Eruption of macroscopic granulomata occurred in the hamster epididymis within 8 weeks of the operation and about 30% of these animals showed a terminal cyst at the site of obstruction. Epididymal granulomata were not observed as frequently in rats as in the other species. The disposal of spermatozoa was found to depend on their ingestion by leucocytes which enter the tract through the granulomata and by epitheloid cells within the terminal vasal cysts. Ipsilateral di sruption of the seminiferous epithelium was consistently observed in association with granulomata and/or distension of the caput or corpus epididymis. The effect of unilateral vasectomy in rats and rabbits demonstrated that vasectomy had no general immunologically mediated suppressive effect on the potential fertility of these animals.