Obesity, physical activity and the risk of pancreatic cancer in a large Japanese cohort
Obesity, physical activity and the risk of pancreatic cancer in a large Japanese cohort
复制标题
DOI：
10.1002/ijc.22614
复制
发表时间：
2007-06-15
影响因子：
6.4
通讯作者：
Ishibashi, Teruo
中科院分区：
文献类型：
--
作者：
Lin, Yingsong;Kikuchi, Shogo;Ishibashi, Teruo
目前尚不清楚体重指数（BMI）和体力活动是否与亚洲人群中胰腺癌的风险相关。我们在日本癌症风险评估协作队列研究中检查了这些相关性。我们的队列研究纳入了110，792名日本男性和女性（1988-1990）。身高、体重（基线和20岁时）和体力活动数据来自调查问卷。考克斯比例风险模型用于估计胰腺癌死亡率的相对风险。在随访期间，我们观察到总共有402例胰腺癌死亡。20岁时BMI为30或更高的男性与BMI正常的男性相比，风险高3.5倍。基线时BMI为27.5-29.9的女性与BMI为20.0-22.4的女性相比，风险增加了60%。在男性中，20岁和基线年龄之间体重减轻5 kg或更多与胰腺癌死亡风险增加相关。相比之下，在同一时期体重减轻5公斤或更多的女性风险降低。体力活动与男性或女性的胰腺癌风险无关。在日本男性中，成年早期肥胖可能与胰腺癌死亡风险增加有关。胰腺癌的风险与BMI的关系似乎因性别和BMI测量时间而异。(c)2007 Wiley-Liss，Inc.
It is unclear whether body mass index (BMI) and physical activity are associated with the risk of pancreatic cancer in Asian populations. We examined these associations in the Japanese Collaborative Cohort Study for Evaluation of Cancer Risk. Our cohort study included 110,792 Japanese men and women at enrollment (1988-1990). Data on height, body weight (at baseline and age 20 years) and physical activity were obtained from a questionnaire. Cox proportional hazards models were used to estimate the relative risks of pancreatic cancer mortality. We observed a total or 402 pancreatic cancer deaths during the follow-up period. Men with a BMI of 30 or more at age 20 years had a 3.5-fold greater risk compared with men with a normal BMI. Women with a BMI of 27.5-29.9 at baseline had similar to 60% increased risk compared with women with a BMI of 20.0-22.4. In men, weight loss of 5 kg or more between 20 years of age and baseline age was associated with an increased risk of pancreatic cancer death. In contrast, women with weight loss of 5 kg or more over the same period had a decreased risk. Physical activity was not associated with pancreatic cancer risk in either men or women. Obesity in young adulthood may be associated with an increased risk of death from pancreatic cancer in Japanese men. The risk of pancreatic cancer in relation to BMI seems to differ according to sex and the period over which BMI was measured. (c) 2007 Wiley-Liss, Inc.