CTCF mediates long-range interaction between silencer Sis and enhancer Ei and inhibits VJ rearrangement in pre-B cells

CTCF mediates long-range interaction between silencer Sis and enhancer Ei and inhibits VJ rearrangement in pre-B cells
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CTCF介导沉默子Sis和增强子Ei之间的长程相互作用并抑制前B细胞中的VJ重排

DOI:
10.5114/ceji.2013.37750
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发表时间:
2013-10
影响因子:
1.3
通讯作者:
Zhe Liu
Zhe Liu
中科院分区:
医学4区
文献类型:
--
作者:
Litao Qin;Qing Niu;Xichuan Li;Xiaoting Li;Zhenjie Liu;Zhao Xu;Zhenyi Ma;Zhi Yao;Zhe Liu

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Igκ VJ rearrangement occurs only in one allele. It is not fully understood how this allelic exclusion is regulated. We previously identified a recombination silencer and heterochromatin targeting element in the mouse Igκ gene locus, which is termed Sis. U
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