Two-layer multiplexed peristaltic pumps for high-density integrated microfluidics
Two-layer multiplexed peristaltic pumps for high-density integrated microfluidics
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DOI：
10.1016/j.snb.2010.07.012
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发表时间：
2011-01-28
影响因子：
8.4
通讯作者：
Kenis, Paul J. A.
中科院分区：
文献类型：
--
作者：
Cole, Matthew C.;Desai, Amit V.;Kenis, Paul J. A.
为了在单个微流控芯片上实现更复杂和集成的化学和生物过程，需要大量组件的集成和操作。这些芯片的功能通常受到单个芯片上可控制的泵和阀的最大数量的限制，这通常是由辅助硬件可用的气动互连数量决定的。在这里，我们报告了一种多路复用方法，该方法大大减少了运行大量蠕动泵所需的外部气动连接数量。该方法的实用性通过一个复杂的微流体网络来证明，该网络能够在两相流中产生和路由液滴。在研究了每台泵的阀数和阀与阀之间的距离对蠕动泵性能的影响的基础上，我们还报告了一套用于多路蠕动泵设计和运行的设计规则。本文报道的多路复用方法可以广泛应用于化学和生物应用的微流控芯片，特别是那些需要在单个芯片上集成许多不同操作的微流控芯片，以及那些需要以亚纳升的体积大规模并行执行类似操作的微流控芯片。(C) 2010 Elsevier B.V.版权所有
The integration and operation of a large number of components is needed to enable ever more complex and integrated chemical and biological processes on a single microfluidic chip. The capabilities of these chips are often limited by the maximum number of pumps and valves that can be controlled on a single chip, a limitation typically set by the number of pneumatic interconnects available from ancillary hardware. Here, we report a multiplexing approach that greatly reduces the number of external pneumatic connections needed for the operation of a large number of peristaltic pumps. The utility of the approach is demonstrated with a complex microfluidic network capable of generating and routing liquid droplets in a two-phase flow. We also report a set of design rules for the design and operation of multiplexed peristaltic pumps, based on a study of the effect of the number of valves per pump and the valve-to-valve distance on the performance of peristaltic pumps. The multiplexing approach reported here may find application in a wide range of microfluidic chips for chemical and biological applications, especially those that require the integration of many different operations on a single chip and those that need to perform similar operations massively in parallel, in sub-nanoliter volumes. (C) 2010 Elsevier B.V. All rights reserved.