HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype.
HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype.
复制标题
喀麦隆农村雨林居民的 HLA I 类多样性：A*2612-B*4407 单倍型的鉴定。
DOI：
10.1111/j.1399-0039.2005.00527.x
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Carrington,M
中科院分区：
文献类型：
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作者：
Torimiro,JN;Carr,JK;Wolfe,ND;Karacki,P;Martin,MP;Gao,X;Tamoufe,U;Thomas,A;Ngole,EM;Birx,DL;McCutchan,FE;Burke,DS;Carrington,M
The population distribution of alleles of the classical HLA class I loci in Cameroon has not been well studied but is of particular interest given the AIDS and malarial epidemics afflicting this population. We investigated the genetic diversity of HLA‐A, HLA‐B and HLA‐C alleles in remote populations of Cameroon. Subjects from seven small, isolated, indigenous populations (N= 274) in the rainforest of southern Cameroon were typed for HLA‐A, HLA‐B and HLA‐C alleles using a polymerase chain reaction/sequence‐specific oligonucleotide probe assay and sequence analysis. Multiple alleles of the HLA‐A (N= 28), HLA‐B (N= 41) and HLA‐C (N= 21) loci were identified, of whichA*2301[allele frequency (AF) = 12.8%],B*5802(AF = 10.9%) andCw*0401(AF = 16.6%) were the most frequent individual alleles andA*02(AF = 19.0%),B*58(AF = 15.9%) andCw*07(AF = 22.4%) the most common serologically defined groups of alleles. Twenty‐six (28.9%) alleles with a frequency of less than 1% (AF < 1%), 39 (43%) with a frequency of 2.0–15.0% (AF = 2.0–15.0%), three globally uncommon alleles [A*2612(AF = 2.0%),B*4016(AF = 0.7%) andB*4407(AF = 1.4%)], and theA*2612‐Cw*0701/06/18‐B*4407haplotype (haplotype frequency = 1.3%) were also identified. Heterozygosity values of 0.89, 0.92 and 0.89 were determined forHLA‐A,HLA‐BandHLA‐C, respectively. The extensive allelic and haplotypic diversity observed in this population may have resulted from varied natural selective pressures on the population, as well as intermingling of peoples from multiple origins. Thus, from an anthropologic perspective, these data highlight the challenges in T–cell‐based vaccine development, the identification of allogeneic transplant donors and the understanding of infectious disease patterns in different populations.
