Impact of metabolic syndrome on cognition and brain: a selected review of the literature.
Impact of metabolic syndrome on cognition and brain: a selected review of the literature.
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代谢综合征对认知和大脑的影响：文献的选定评论。
DOI：
10.1161/atvbaha.112.252759
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Convit A
中科院分区：
文献类型：
--
作者：
Yates KF;Sweat V;Yau PL;Turchiano MM;Convit A
代谢综合征(METS)是2型糖尿病和心血管疾病的危险因素聚集，与认知功能障碍和脑异常有关。本文综述了有关蛋氨酸对大脑和认知的影响的文献，并对未来的研究方向提出了建议。对非老年成年人和青少年进行了关于代谢综合征与认知和脑成像的文献搜索。没有发现描述蛋氨酸与青少年大脑或认知的研究；因此，我们也纳入了调查该年龄组中蛋氨酸的个体成分的研究。大多数研究发现，Met与认知功能障碍之间存在关联。甲硫氨酸对成人的多个认知领域有影响。在青少年中，大多数研究结果是在执行功能方面。成年人的脑成像文献表明，甲硫氨酸与缺血性中风、脑白质改变和大脑代谢改变有关。对于青少年来说，单独的METS因素与海马体和额叶的体积减少有关。代谢综合征会对认知能力和大脑结构产生负面影响。可能的解释模型包括血管反应性受损、神经炎症、氧化应激和脑脂代谢异常。我们推测胰岛素抵抗相关的脑血管反应性损害是甲硫氨酸脑病脑缺陷的一个重要机制。
Metabolic Syndrome (MetS), a clustering of risk factors for type 2 diabetes mellitus and cardiovascular disease, has been associated with cognitive dysfunction and brain abnormalities. This review describes the literature on the impact of MetS on brain and cognition and suggests directions for future research. A literature search for reports of MetS and cognition and brain imaging was conducted for both non-elderly adults and adolescents. No studies were found describing MetS and brain or cognition among adolescents; therefore we also included studies investigating individual components of MetS in this age group. Most studies found associations between MetS and cognitive dysfunction. Multiple cognitive domains were affected by MetS in adults. In adolescents, the majority of findings were in executive functioning. Brain imaging literature in adults implicated MetS in ischemic stroke, white matter alterations and altered brain metabolism. For adolescents, individual MetS factors were linked to volume losses in the hippocampus and frontal lobes. MetS negatively impacts cognitive performance and brain structure. Potential explanatory models include impaired vascular reactivity, neuroinflammation, oxidative stress, and abnormal brain lipid metabolism. We posit that insulin resistance-associated impairment in cerebrovascular reactivity is an important mechanism underlying brain deficits seen in MetS.