Precision periodontal care: from omics discoveries to chairside diagnostics.
Precision periodontal care: from omics discoveries to chairside diagnostics.
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DOI：
10.1007/s00784-023-04878-7
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发表时间：
2023-03
影响因子：
3.4
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中科院分区：
文献类型：
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分子科学和技术的界面正在引导个性化医疗向精准医疗的转变。蛋白质组学、基因组学、转录组学和代谢组学的应用正在塑造疾病生物标志物的适用性。这些生物标志物在大型和多样化的患者队列中的预先验证有助于验证其临床可用性。将分子发现纳入常规临床实践依赖于定制分析方法和设备的发展，这些方法和设备能够在患者仍在治疗期间将分析数据快速传递给临床医生。目前的观点审查下的棱镜精密牙周保健解决这一问题。提出了一些有前途的研究尝试，以创新口腔诊断技术平台。重点放在(a)唾液作为评估牙周健康的方便取样生物标本的适用性，(b)蛋白质组学作为牙周病生物标志物鉴定的高通量方法，以及(c)椅子旁分子诊断分析作为从实验室台式过渡到临床护理点的技术渠道。
The interface of molecular science and technology is guiding the transformation of personalized to precision healthcare. The application of proteomics, genomics, transcriptomics, and metabolomics is shaping the suitability of biomarkers for disease. Prior validation of such biomarkers in large and diverse patient cohorts helps verify their clinical usability. Incorporation of molecular discoveries into routine clinical practice relies on the development of customized assays and devices that enable the rapid delivery of analytical data to the clinician, while the patient is still in session. The present perspective review addresses this topic under the prism of precision periodontal care. Selected promising research attempts to innovate technological platforms for oral diagnostics are brought forward. Focus is placed on (a) the suitability of saliva as a conveniently sampled biological specimen for assessing periodontal health, (b) proteomics as a high-throughput approach for periodontal disease biomarker identification, and (c) chairside molecular diagnostic assays as a technological funnel for transitioning from the laboratory benchtop to the clinical point-of-care.