Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: insight into functional group effects and biological activity.
Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: insight into functional group effects and biological activity.
复制标题
抗肿瘤剂赤霉素的合成和聚合物封装同系物的制备和生物学评价：深入了解官能团效应和生物活性。
DOI：
10.1016/j.bmc.2015.02.022
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发表时间：
2015
影响因子：
3.5
通讯作者：
Johnson,JeffreyS
中科院分区：
文献类型：
--
作者：
Sharpe,RobertJ;Malinowski,JustinT;Sorana,Federico;Luft,JChristopher;Bowerman,CharlesJ;DeSimone,JosephM;Johnson,JeffreyS
氨基环醇类抗生素帕塔霉素的快速全合成在第二章中有描述。 1 ，使得能够从商业上可获得的材料十五步制备天然产物。虽然具有一系列有价值的生物学特性，但其高细胞毒性阻碍了药物开发。
An expeditious total synthesis of the aminocyclitol antibiotic pactamycin was described in Chap. 1 , enabling fifteen-step preparation of the natural product from commercially available materials. Pactamycin, while bearing a remarkable array of valuable biological traits, is hindered in medicinal development by its high cytotoxicity.