Natural-based chiral task-specific deep eutectic solvents: A novel, effective tool for enantiodiscrimination in electroanalysis
Natural-based chiral task-specific deep eutectic solvents: A novel, effective tool for enantiodiscrimination in electroanalysis
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DOI：
10.1016/j.electacta.2021.138189
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发表时间：
2021-04-01
影响因子：
6.6
通讯作者：
Mussini, Patrizia Romana
中科院分区：
文献类型：
--
作者：
Arnaboldi, Serena;Mezzetta, Andrea;Mussini, Patrizia Romana
深铕溶剂（DES）提供了类似于离子液体（IL）的优点，合成更容易，更可持续;此外，生物基DES通常包括手性组分，令人惊讶的是未被充分利用。现在提供了对映体纯手性DES作为对映体选择性电分析手性介质的令人印象深刻的潜力的概念证明。本文介绍了三种手性电极电极，它们是由一种分子盐和三种天然的和/或低成本的伙伴（乙酰丙酸、甘油和尿素）组成的生物基手性阳离子[NopolMIm]（+），并作为手性伏安介质进行了研究。对于模型手性探针的对映异构体观察到显著的电位差，根据非手性DES组分进行显著的调节，在乙酰丙酸的情况下达到令人印象深刻的类似于0.5 V（而在IL中作为手性添加剂出现效率较低的[NopolMIm]（+））。用同样的介质，也观察到良好的对映体歧视的氨基酸色氨酸，一个非常不同的探针和应用的兴趣。这些发现可以被认为是一个显着的一步，进一步在手性电分析，以及在特定任务的对映选择性介质的发展。(C)2021爱思唯尔有限公司保留所有权利。
Deep Eutectic Solvents (DESs) offer advantages similar to ionic liquid (IL) ones, with easier and more sustainable synthesis; moreover, bio-based DESs often include chiral components, surprisingly underexploited. A proof of concept is now offered of the impressive potential of enantiopure chiral DESs as chiral media for enantioselective electroanalysis. Three chiral DESs, consisting of a molecular salt with bio-based chiral cation [NopolMIm](+) combined with three natural and/or low-cost partners (levulinic acid, glycerol and urea), are introduced and investigated as chiral voltammetry media. Significant potential differences are observed for the enantiomers of a model chiral probe, with a dramatic tuning depending on the achiral DES component, reaching an impressive similar to 0.5 V in the levulinic acid case (while less efficient appears [NopolMIm](+) as chiral additive in IL). With the same medium good enantiodiscrimination is also observed for aminoacid tryptophan, a quite different probe and of applicative interest. These findings can be considered as a remarkable step further in chiral electroanalysis as well as in the development of task-specific enantioselective media. (C) 2021 Elsevier Ltd. All rights reserved.