A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities.
A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities.
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共享的空间拓扑将可卡因使用障碍和多巴胺 D2/3 受体密度的功能连接组相关联。
DOI：
10.1101/2023.11.17.567591
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Holmes,AvramJ
中科院分区：
文献类型：
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作者：
Ricard,JocelynA;Labache,Loïc;Segal,Ashlea;Dhamala,Elvisha;Cocuzza,CarrisaV;Jones,Grant;Yip,Sarah;Chopra,Sidhant;Holmes,AvramJ
导致可卡因和其他物质使用障碍的生物机制涉及一系列皮质和皮质下系统。之前关于物质使用的发展和维持的工作主要集中在皮质-纹状体回路上，相对较少关注大规模功能性脑网络内和跨大规模功能性脑网络的改变，以及多巴胺系统的相关方面。在这里，我们的特点可卡因使用障碍的功能连接模式和它们的空间关联与神经递质受体密度和转运蛋白结合通过PET评估。可卡因使用障碍中的功能连接特征与独立数据集上多巴胺D2/3受体的空间密度可靠相关。这些发现表明，多巴胺受体密度的地形图可能是可卡因使用障碍的功能连接模式的基础，通过功能磁共振成像评估。
The biological mechanisms that contribute to cocaine and other substance use disorders involve an array of cortical and subcortical systems. Prior work on the development and maintenance of substance use has largely focused on cortico-striatal circuits, with relatively less attention on alterations within and across large-scale functional brain networks, and associated aspects of the dopamine system. Here, we characterize patterns of functional connectivity in cocaine use disorder and their spatial association with neurotransmitter receptor densities and transporter bindings assessed through PET. Profiles of functional connectivity in cocaine use disorder reliably linked with spatial densities of dopamine D2/3receptors across independent datasets. These findings demonstrate that the topography of dopamine receptor densities may underlie patterns of functional connectivity in cocaine use disorder, as assessed through fMRI.