Ethylglucuronide in the urine as a marker of alcohol consumption during pregnancy: Comparison with four alcohol screening questionnaires
Ethylglucuronide in the urine as a marker of alcohol consumption during pregnancy: Comparison with four alcohol screening questionnaires
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DOI：
10.1016/j.toxlet.2017.04.016
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发表时间：
2017-06-05
影响因子：
3.5
通讯作者：
Ceccanti, Mauro
中科院分区：
文献类型：
--
作者：
Ferraguti, Giampiero;Ciolli, Paola;Ceccanti, Mauro
乙基葡萄糖醛酸苷（EtG）是一种乙醇代谢产物，被用作饮酒的生物标志物。EtG可以在血液和几种生物基质中检测到，包括尿液，头发和指甲。怀孕期间饮酒是胎儿健康的一个强有力的危险因素，因此近年来，人们计划采用不同的策略来揭示饮酒情况，包括使用筛查问卷，如AUDIT-C、T-ACE和TWEAK。本研究旨在调查孕妇AUDIT-C，T-ACE和TWEAK加食物日记在Sapienza大学医院使用的特异性和预测价值相比，尿EtG测量的结果。70名孕妇入组并接受检查。孕妇在面谈后立即提供尿样。通过酶免疫测定法进行EtG测定，截止值确定为100 ng/mL。数据显示，34.28%的入选孕妇超过了EtG截止值。EtG数据和酒精筛查访谈之间没有发现直接相关性，显示酒精消费水平较低，尽管T-ACE显示风险百分比相同。然而，仅在EtG尿浓度较高的患者中观察到食物日记数据和T-ACE的显著一致性。这项研究提供的临床证据表明，仅基于问卷调查和食物日记等间接方法诊断妊娠期母亲饮酒可能会显著低估酒精使用。
Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strategies to reveal alcohol use have been planning including the use of screening questionnaires as the AUDIT-C, T-ACE and TWEAK. The present study aims to investigate in pregnant women the specificity and predictive value of the AUDIT-C, T-ACE and TWEAK plus a food diary in use in Sapienza University Hospital compared with the results of urine EtG measurement. Seventy pregnant women were enrolled and examined. Urine samples were provided by pregnant women immediately after the interviews. EtG determinations were performed liy Enzyme Immunoassay with a cut-off established at 100 ng/mL.Data show that 34.28% of the enrolled pregnant women overcame the EtG cut off. No direct correlation was found between EtG data and the alcohol screening interviews showing lower levels of alcohol consumption, although T-ACE revealed the same at risk percentage. However, a significant concordance was observed with food diary data and T-ACE only in patients with higher EtG urinary concentration. This study provides clinical evidence that the diagnosis of maternal alcohol consumption during pregnancy only based on indirect methods, such as questionnaires and food diary, may significantly underestimate alcohol use.