Viral glycoproteins: biological role and application in diagnosis.
Viral glycoproteins: biological role and application in diagnosis.
复制标题
DOI：
10.1007/s13337-015-0293-5
复制
发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Mukhopadhyay S
中科院分区：
文献类型：
--
作者：
Banerjee N;Mukhopadhyay S
感染人类的病毒造成了巨大的全球疾病负担，并对医疗保健系统产生了巨大的挑战。糖蛋白是人类致病病毒的主要成分之一。它们已被证明在感染和免疫中具有重要作用。同时，针对这些抗原性病毒糖蛋白的高滴度抗体为开发新的诊断方法铺平了道路。适当的生物标志物的可用性对于传染病的提前诊断是必要的，特别是在爆发的情况下。随着当今人类动员的增加，传染性病原体的传播变得更快，这为快速诊断系统的需求铺平了道路。在病毒感染的情况下，这是一个紧急的病毒传播和变异非常快。这篇评论围绕病毒糖蛋白的广阔竞技场，他们在健康和疾病的重要性和他们的诊断应用。
The viruses that infect humans cause a huge global disease burden and produce immense challenge towards healthcare system. Glycoproteins are one of the major components of human pathogenic viruses. They have been demonstrated to have important role(s) in infection and immunity. Concomitantly high titres of antibodies against these antigenic viral glycoproteins have paved the way for development of novel diagnostics. Availability of appropriate biomarkers is necessary for advance diagnosis of infectious diseases especially in case of outbreaks. As human mobilization has increased manifold nowadays, dissemination of infectious agents became quicker that paves the need of rapid diagnostic system. In case of viral infection it is an emergency as virus spreads and mutates very fast. This review encircles the vast arena of viral glycoproteins, their importance in health and disease and their diagnostic applications.